Rep Rab escort protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Repprovided by FlyBase
Official Full Name: Rab escort proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0026378
Locus tag: Dmel_CG8432
See related: AllianceGenome:FB:FBgn0026378
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8432; Dmel\CG8432; rep; REP
Summary: Predicted to enable GDP-dissociation inhibitor activity. Involved in positive regulation of protein localization to endoplasmic reticulum and protein geranylgeranylation. Located in aster; perinuclear region of cytoplasm; and spindle pole. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in asthma and choroideremia. Orthologous to human CHM (CHM Rab escort protein) and CHML (CHM like Rab escort protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19492087..19494125)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15379592..15381630)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein localization to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rab-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Rab-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in aster	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain