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    Mctp Multiple C2 domain and transmembrane region protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37165, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Mctpprovided by FlyBase
    Official Full Name
    Multiple C2 domain and transmembrane region proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034389
    Locus tag
    Dmel_CG15078
    See related
    AllianceGenome:FB:FBgn0034389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15078; CG33146; CG33148; Dmel\CG15078; DmMCTP; mctp
    Summary
    Enables calcium ion binding activity. Involved in regulation of neuronal synaptic plasticity and regulation of neurotransmitter secretion. Located in endoplasmic reticulum membrane. Is expressed in adult head; olfactory sensory organ; and organism. Orthologous to several human genes including MCTP1 (multiple C2 and transmembrane domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Mctp in Genome Data Viewer
    Location:
    55F1-55F2; 2-86 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18761758..18774824)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14649263..14662329)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-A Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12b2 Neighboring gene jabba Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene antisense RNA:CR43964 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. Genç Ö, et al. Elife, 2017 May 9. PMID 28485711, Free PMC Article
    2. Epistatic selection on a selfish Segregation Distorter supergene - drive, recombination, and genetic load. Navarro-Dominguez B, et al. Elife, 2022 Apr 29. PMID 35486424, Free PMC Article
    3. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. Shin OH, et al. J Biol Chem, 2005 Jan 14. PMID 15528213
    4. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article
    5. A screen for genes expressed in the olfactory organs of Drosophila melanogaster identifies genes involved in olfactory behaviour. Tunstall NE, et al. PLoS One, 2012. PMID 22530061, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multiple C2 domain and transmembrane region protein
    Names
    CG15078-PA
    CG15078-PB
    CG15078-PD
    CG15078-PE
    CG15078-PF
    CG15078-PG
    Mctp-PA
    Mctp-PB
    Mctp-PD
    Mctp-PE
    Mctp-PF
    Mctp-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18761758..18774824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299661.1 → NP_001286590.1  multiple C2 domain and transmembrane region protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286590.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBD6
      Conserved Domains (4) summary
      cd04042
      Location:218 → 338
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:371 → 478
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:518 → 639
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:770 → 874
      PRT_C; Plant phosphoribosyltransferase C-terminal

    2. NM_001274149.1 → NP_001261078.1  multiple C2 domain and transmembrane region protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBD6
      Conserved Domains (4) summary
      cd04042
      Location:237 → 357
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:390 → 497
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:537 → 658
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:789 → 893
      PRT_C; Plant phosphoribosyltransferase C-terminal

    3. NM_001316428.1 → NP_001303357.1  multiple C2 domain and transmembrane region protein, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KEZ6, A0A0C4DHG8, A0A126GUP9, A1ZBD6
      Conserved Domains (4) summary
      cd04042
      Location:237 → 357
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:390 → 497
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:537 → 658
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:789 → 893
      PRT_C; Plant phosphoribosyltransferase C-terminal

    4. NM_137528.5 → NP_611372.3  multiple C2 domain and transmembrane region protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611372.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBD6
      Conserved Domains (4) summary
      cd04042
      Location:218 → 338
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:371 → 478
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:518 → 639
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:770 → 874
      PRT_C; Plant phosphoribosyltransferase C-terminal

    5. NM_001043094.2 → NP_001036559.2  multiple C2 domain and transmembrane region protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036559.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBD6
      Conserved Domains (4) summary
      cd04042
      Location:279 → 399
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:432 → 539
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:579 → 700
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:831 → 935
      PRT_C; Plant phosphoribosyltransferase C-terminal

    6. NM_001043095.3 → NP_001036560.1  multiple C2 domain and transmembrane region protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZN2
      Conserved Domains (3) summary
      cd08376
      Location:74 → 181
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:221 → 342
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:473 → 577
      PRT_C; Plant phosphoribosyltransferase C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBD6.3 A1ZBD6
    Q7JZN2 Q7JZN2

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