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    Elk Eag-like K[+] channel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37047, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Elkprovided by FlyBase
    Official Full Name
    Eag-like K[+] channelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011589
    Locus tag
    Dmel_CG5076
    See related
    AllianceGenome:FB:FBgn0011589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5076; dmELK; Dmel\CG5076; elk
    Summary
    Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of plasma membrane. Is expressed in adult head and adult heart. Orthologous to several human genes including KCNH3 (potassium voltage-gated channel subfamily H member 3) and KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Elk in Genome Data Viewer
    Location:
    54F4-55A2; 2-84 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17873939..17926695)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13761444..13814200)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44417 Neighboring gene uncharacterized protein Neighboring gene mapmodulin Neighboring gene three rows Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Prophenoloxidase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44418 Neighboring gene Protein phosphatase Y at 55A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels. Adaixo R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823525, Free PMC Article
    2. Structural basis of two-stage voltage-dependent activation in K+ channels. Silverman WR, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12606713, Free PMC Article
    3. The eag family of K+ channels in Drosophila and mammals. Ganetzky B, et al. Ann N Y Acad Sci, 1999 Apr 30. PMID 10414305
    4. Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. Jegla T, et al. PLoS Genet, 2016 Dec. PMID 27911898, Free PMC Article
    5. Evolutionary analysis of voltage-gated potassium channels by Bayes method. Huang Q, et al. J Mol Neurosci, 2014 May. PMID 24318840

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. packing arrangement of protein molecules in the dmELK crystals was determined to belong to space group P4132, with two molecules in the asymmetric unit
      Title: Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in potassium ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Eag-like K[+] channel
    Names
    CG5076-PA
    CG5076-PB
    Elk-PA
    Elk-PB
    eag-like K+ channel
    eag-like K[+] channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17873939..17926695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299624.1 → NP_001286553.1  Eag-like K[+] channel, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGW2, Q23974
      Conserved Domains (6) summary
      COG0664
      Location:582 → 649
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:585 → 714
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:36 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:280 → 515
      Ion_trans; Ion transport protein
      pfam07885
      Location:454 → 509
      Ion_trans_2; Ion channel
      pfam08447
      Location:41 → 129
      PAS_3; PAS fold

    2. NM_057661.3 → NP_477009.1  Eag-like K[+] channel, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB14, Q23974
      Related
      FBpp0085981
      Conserved Domains (6) summary
      COG0664
      Location:583 → 650
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:586 → 715
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:36 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:285 → 516
      Ion_trans; Ion transport protein
      pfam07885
      Location:455 → 510
      Ion_trans_2; Ion channel
      pfam08447
      Location:41 → 129
      PAS_3; PAS fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGW2 A0A0B4LGW2
    A1ZB14 A1ZB14
    Q23974 Q23974

    Gene LinkOut

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