Glra4 glycine receptor alpha 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glra4provided by RGD
Official Full Name: glycine receptor alpha 4provided by RGD
Primary source: RGD:1564103
See related: EnsemblRapid:ENSRNOG00000002391 AllianceGenome:RGD:1564103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564103
Summary: Predicted to enable extracellularly glycine-gated chloride channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and response to amino acid. Predicted to be part of transmembrane transporter complex. Predicted to be active in glycinergic synapse; neuron projection; and postsynaptic specialization membrane. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 29.2), Kidney (RPKM 10.2) and 9 other tissues See more
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Genomic context

Location:: Xq32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (104899449..104923328, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (100110517..100131042, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (107416019..107447253, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU049455 (e-PCR)
- UniSTS:145902

NoName (e-PCR)
- UniSTS:487420

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycine receptor subunit alpha-4

Names: glycine receptor, alpha 4 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191914.1 → NP_001178843.1 glycine receptor subunit alpha-4 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2JW26, D4A4R5

Related

ENSRNOP00000042161.3, ENSRNOT00000052302.6

Conserved Domains (1) summary

TIGR00860
Location:9 → 444

LIC; Cation transporter family protein