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    lbk lambik [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36788, updated on 11-Sep-2024

    Summary

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    Official Symbol
    lbkprovided by FlyBase
    Official Full Name
    lambikprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034083
    Locus tag
    Dmel_CG8434
    See related
    AllianceGenome:FB:FBgn0034083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8434; Dmel\CG8434; Lbk
    Summary
    Involved in positive regulation of BMP signaling pathway. Predicted to be integral component of plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in adult head; embryonic/larval peripheral nervous system; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to several human genes including LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See lbk in Genome Data Viewer
    Location:
    52F1-52F3; 2-78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16150123..16169519)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12037628..12057024)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cysteinyl-tRNA synthetase Neighboring gene sister of tout-velu Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45993 Neighboring gene long non-coding RNA:CR45994 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase 52F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient Screening of CRISPR/Cas9-Induced Events in Drosophila Using a Co-CRISPR Strategy. Kane NS, et al. G3 (Bethesda), 2017 Jan 5. PMID 27793971, Free PMC Article
    2. C. elegans SMA-10 regulates BMP receptor trafficking. Gleason RJ, et al. PLoS One, 2017. PMID 28704415, Free PMC Article
    3. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
    4. Modeling the cis-regulatory modules of genes expressed in developmental stages of Drosophila melanogaster. López Y, et al. PeerJ, 2017. PMID 28584716, Free PMC Article
    5. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 16152235-16152591 mobile_element_type = transposon:INE-1{}6175

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lambik
    Names
    CG8434-PB
    kekkon-like
    lbk-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16150123..16169519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137247.3 → NP_611091.2  lambik [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611091.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAB1
      Conserved Domains (8) summary
      cd00096
      Location:735 → 823
      Ig; Immunoglobulin domain
      smart00082
      Location:665 → 712
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:936 → 1027
      IG; Immunoglobulin
      cd00116
      Location:498 → 669
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:834 → 924
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:363 → 386
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:316 → 373
      LRR_8; Leucine rich repeat
      cl11960
      Location:851 → 924
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAB1 A1ZAB1
    Q95RL4 Q95RL4

    Gene LinkOut

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