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    Got1 Glutamate oxaloacetate transaminase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36782, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Got1provided by FlyBase
    Official Full Name
    Glutamate oxaloacetate transaminase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0001124
    Locus tag
    Dmel_CG8430
    See related
    AllianceGenome:FB:FBgn0001124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH07823; CG8430; Dmel\CG8430; FBgn 1124; Got-1; GOT-1; got1; GOT1; Got2
    Summary
    Enables L-aspartate:2-oxoglutarate aminotransferase activity. Involved in glutamate biosynthetic process. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval muscle cell; gastrula embryo; gut section; and midline ventral glial cell. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to several human genes including GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Got1 in Genome Data Viewer
    Location:
    52E7-52E10; 2-77 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16138352..16141928)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12025857..12029433)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene spinster Neighboring gene uncharacterized protein Neighboring gene Cysteinyl-tRNA synthetase Neighboring gene sister of tout-velu

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetics of glutamate oxaloacetate transaminase in Drosophila melanogaster. Cavener DR, et al. J Hered, 1976 Sep-Oct. PMID 827557
    2. Genetic analysis of aspartate aminotransferase isozymes from hybrids between Drosophila melanogaster and Drosophila simulans and mutagen-induced isozyme variants. Grell EH. Genetics, 1976 Aug. PMID 823072, Free PMC Article
    3. A survey of isozyme polymorphism in a Drosophila melanogaster natural population. Band HT. Genetics, 1975 Aug. PMID 811501, Free PMC Article
    4. A genetic analysis of glutamatergic function in Drosophila. Chase BA, et al. J Neurobiol, 1987 Jan. PMID 3106567
    5. C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in Drosophila Glutamatergic Neurons. Xu W, et al. J Neurosci, 2018 Aug 29. PMID 30037833, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aspartate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate oxaloacetate transaminase 1
    Names
    CG8430-PA
    CG8430-PB
    Got1-PA
    Got1-PB
    glutamate oxaloacetic transaminase
    NP_611086.1
    NP_725534.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16138352..16141928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166148.2 → NP_725534.1  glutamate oxaloacetate transaminase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAA5, Q8IHB4
      Related
      FBpp0086370
      Conserved Domains (2) summary
      PTZ00376
      Location:21 → 423
      PTZ00376; aspartate aminotransferase; Provisional
      pfam00155
      Location:49 → 418
      Aminotran_1_2; Aminotransferase class I and II

    2. NM_137242.3 → NP_611086.1  glutamate oxaloacetate transaminase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K221, Q7YWB4
      Related
      FBpp0086371
      Conserved Domains (2) summary
      PTZ00376
      Location:1 → 402
      PTZ00376; aspartate aminotransferase; Provisional
      pfam00155
      Location:28 → 397
      Aminotran_1_2; Aminotransferase class I and II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAA5 A1ZAA5
    Q7K221 Q7K221
    Q7YWB4 Q7YWB4
    Q8IHB4 Q8IHB4

    Gene LinkOut

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