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    eIF2Bgamma eukaryotic translation initiation factor 2B subunit gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36722, updated on 11-Sep-2024

    Summary

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    Official Symbol
    eIF2Bgammaprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 2B subunit gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034029
    Locus tag
    Dmel_CG8190
    See related
    AllianceGenome:FB:FBgn0034029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8190; Dmel\CG8190; eIF2B-gamma
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and translation initiation factor activity. Involved in cellular response to hypoxia. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See eIF2Bgamma in Genome Data Viewer
    Location:
    52A10-52A10; 2-74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15542661..15544409)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11430166..11431914)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45927 Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 36kD subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
    2. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
    3. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling. Machado Almeida P, et al. Nat Commun, 2021 Oct 1. PMID 34599173, Free PMC Article
    4. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article
    5. Improvement of phosphoproteome analyses using FAIMS and decision tree fragmentation. application to the insulin signaling pathway in Drosophila melanogaster S2 cells. Bridon G, et al. J Proteome Res, 2012 Feb 3. PMID 22059388

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2B subunit gamma
    Names
    CG8190-PA
    eIF2B-gamma
    eIF2Bgamma-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15542661..15544409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137202.3 → NP_611046.2  eukaryotic translation initiation factor 2B subunit gamma [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611046.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA22, Q8MPP2, Q8MSR4, Q9GQ88
      Related
      FBpp0086469
      Conserved Domains (3) summary
      cd04652
      Location:357 → 437
      LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
      cd04198
      Location:4 → 215
      eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      COG1208
      Location:5 → 441
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA22 A1ZA22
    Q8MPP2 Q8MPP2
    Q8MSR4 Q8MSR4
    Q9GQ88 Q9GQ88

    Gene LinkOut

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