Il27 interleukin 27 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il27provided by RGD
Official Full Name: interleukin 27provided by RGD
Primary source: RGD:1561420
See related: EnsemblRapid:ENSRNOG00000019170 AllianceGenome:RGD:1561420
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561420
Summary: Predicted to enable interleukin-27 receptor binding activity. Involved in response to Gram-positive bacterium. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 3.7), Thymus (RPKM 3.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190603684..190609292, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181173108..181178720, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198003615..198010112, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of interleukin-27 on the rats with preeclampsia and its potential molecular mechanism.
Title: Effects of interleukin-27 on the rats with preeclampsia and its potential molecular mechanism.
IL-27 attenuates IL-23 mediated inflammatory arthritis.
Title: IL-27 attenuates IL-23 mediated inflammatory arthritis.
Impacts of IL-27 and IL-32 in the pathogenesis and outcome of COVID-19 associated mucormycosis.
Title: Impacts of IL-27 and IL-32 in the pathogenesis and outcome of COVID-19 associated mucormycosis.
the results demonstrated the pro-inflammatory role of endogenous IL-27 in chronic joint inflammation
Title: Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin.
Title: Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage.
Data show that endogenous interleukins IL-27 and IL-35 (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin like growth factor -1 (IGF-1) had no effect.
Title: The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
These results indicate that IL-27 protects the myocardium against ischemia/reperfusion injury and facilitates the recovery of damaged cardiomyocytes
Title: Interleukin-27, a novel cytokine induced by ischemia-reperfusion injury in rat hearts, mediates cardioprotective effects via the gp130/STAT3 pathway.
the incubation of encephalitogenic T cells devoid of Th17 cells with neutralizing anti-IL-27 antibodies restored the production of IL-17
Title: The suppressive effect of IL-27 on encephalitogenic Th17 cells induced by multiwalled carbon nanotubes reduces the severity of experimental autoimmune encephalomyelitis.
interferon-gamma increases NF-kappaB and cytokine IL-18, but decreases IL-27 in acute pancreatitis
Title: Effect of interferon-γ on NF-κB and cytokine IL-18 and IL-27 in acute pancreatitis.
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Title: Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH131640 (e-PCR)
- UniSTS:214923

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-27 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-27 receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T-helper 1 cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info