Rnaseh2a ribonuclease H2, subunit A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnaseh2aprovided by RGD
Official Full Name: ribonuclease H2, subunit Aprovided by RGD
Primary source: RGD:1307248
See related: EnsemblRapid:ENSRNOG00000003504 AllianceGenome:RGD:1307248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 749.9), Adrenal (RPKM 300.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40091206..40100904)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23186325..23196045)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26074980..26084780, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA-DNA hybrid ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA-DNA hybrid ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA-DNA hybrid ribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication, removal of RNA primer	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mismatch repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ribonuclease H2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonuclease H2 complex	ISO Inferred from Sequence Orthology more info
part_of ribonuclease H2 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ribonuclease H2 subunit A

Names: RNase H2 subunit A; RNase HI large subunit; ribonuclease H2, large subunit; ribonuclease HI large subunit; ribonuclease HI subunit A

NP_001013252.1

EC 3.1.26.4

XP_038953836.1

EC 3.1.26.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013234.2 → NP_001013252.1 ribonuclease H2 subunit A

See identical proteins and their annotated locations for NP_001013252.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q5U209

UniProtKB/TrEMBL

A6IY50, A6IY52

Related

ENSRNOP00000070694.3, ENSRNOT00000083159.3

Conserved Domains (1) summary

cd07181
Location:31 → 251

RNase_HII_eukaryota_like; Eukaryotic RNase HII

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40091206..40100904

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097908.2 → XP_038953836.1 ribonuclease H2 subunit A isoform X1

Conserved Domains (1) summary

cd07181
Location:18 → 158

RNase_HII_eukaryota_like; Eukaryotic RNase HII