U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dgkepsilon Diacyl glycerol kinase epsilon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36408, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dgkepsilonprovided by FlyBase
    Official Full Name
    Diacyl glycerol kinase epsilonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020930
    Locus tag
    Dmel_CG8657
    See related
    AllianceGenome:FB:FBgn0020930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8657; DGKe; dgkepsilon; DGKepsilon; Dmel\CG8657
    Summary
    Enables diacylglycerol kinase activity. Involved in phosphorylation. Is expressed in several structures, including germ band; germ layer; germline cell; larval head; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dgkepsilon in Genome Data Viewer
    Location:
    49C2-49C2; 2-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12757546..12759724)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8645051..8647229)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tafazzin Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene oxen Neighboring gene Nascent polypeptide associated complex protein alpha subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45266

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKepsilon. Frolov MV, et al. Biochim Biophys Acta, 2001 Apr 23. PMID 11336805
    2. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. Zhang N, et al. J Biol Chem, 2012 Jun 15. PMID 22511757, Free PMC Article
    3. The Drosophila MOS ortholog is not essential for meiosis. Ivanovska I, et al. Curr Biol, 2004 Jan 6. PMID 14711418
    4. Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses. Nath AS, et al. Cell Rep, 2022 Mar 1. PMID 35235794
    5. A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer. La Marca JE, et al. Dis Model Mech, 2023 Mar 1. PMID 36861754, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    diacyl glycerol kinase epsilon
    Names
    CG8657-PA
    CG8657-PB
    Dgkepsilon-PA
    Dgkepsilon-PB
    diacylglycerol kinase epsilon
    NP_001286362.1
    NP_725228.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12757546..12759724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165949.2 → NP_725228.1  diacyl glycerol kinase epsilon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD90, O44334, Q7K579
      Related
      FBpp0086966
      Conserved Domains (4) summary
      smart00046
      Location:207 → 331
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:207 → 519
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      pfam00130
      Location:108 → 165
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:355 → 510
      DAGK_acc; Diacylglycerol kinase accessory domain

    2. NM_001299433.1 → NP_001286362.1  diacyl glycerol kinase epsilon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD90, O44334, Q7K579
      Conserved Domains (4) summary
      smart00046
      Location:207 → 331
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:207 → 519
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      pfam00130
      Location:108 → 165
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:355 → 510
      DAGK_acc; Diacylglycerol kinase accessory domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44334 O44334
    Q7K579 Q7K579

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous