Oas2 2'-5' oligoadenylate synthetase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oas2provided by RGD
Official Full Name: 2'-5' oligoadenylate synthetase 2provided by RGD
Primary source: RGD:1359697
See related: EnsemblRapid:ENSRNOG00000049282 AllianceGenome:RGD:1359697
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 2'-5'-oligoadenylate synthetase activity; ATP binding activity; and double-stranded RNA binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of viral genome replication; and positive regulation of cytokine production. Predicted to act upstream of or within RNA catabolic process; interleukin-27-mediated signaling pathway; and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 48.5), Uterus (RPKM 40.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12q16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (41464568..41492036)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (35802824..35830778)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (41341417..41363124)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2'-5'-oligoadenylate synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2'-5'-oligoadenylate synthetase activity	IEA Inferred from Electronic Annotation more info
enables 2'-5'-oligoadenylate synthetase activity	ISO Inferred from Sequence Orthology more info
enables 2'-5'-oligoadenylate synthetase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-27-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of lactation	ISO Inferred from Sequence Orthology more info
involved_in regulation of lactation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to virus	TAS Traceable Author Statement more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase 2

Names: (2-5')oligo(A) synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2

NP_001009715.1

EC 2.7.7.84

XP_038945576.1

EC 2.7.7.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009715.1 → NP_001009715.1 2'-5'-oligoadenylate synthase 2

See identical proteins and their annotated locations for NP_001009715.1

Status: PROVISIONAL

Source sequence(s)

AY230746

UniProtKB/Swiss-Prot

Q5MYU0

UniProtKB/TrEMBL

M0RBB5

Related

ENSRNOP00000103870.1, ENSRNOT00000146981.1

Conserved Domains (2) summary

cd05400
Location:392 → 575

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:530 → 713

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

41464568..41492036

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089648.2 → XP_038945576.1 2'-5'-oligoadenylate synthase 2 isoform X1

Conserved Domains (2) summary

cd05400
Location:196 → 379

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:336 → 518

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus