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    ClC-b Chloride channel-b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36381, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ClC-bprovided by FlyBase
    Official Full Name
    Chloride channel-bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033755
    Locus tag
    Dmel_CG8594
    See related
    AllianceGenome:FB:FBgn0033755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8594; clc-b; Clcn7; DmClC-b; DmClCb; Dmel\CG8594
    Summary
    Enables chloride transmembrane transporter activity. Involved in several processes, including chloride transmembrane transport; positive regulation of phagocytosis; and sensory perception of touch. Located in late endosome and phagolysosome. Is expressed in several structures, including embryonic/larval Malpighian tubule; embryonic/larval circulatory system; embryonic/larval fat body; embryonic/larval gut; and embryonic/larval somatic muscle cell. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ClC-b in Genome Data Viewer
    Location:
    49B5-49B5; 2-67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12572068..12575299)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8459573..8462804)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 301a1 Neighboring gene Adenylate kinase 6 Neighboring gene stand still Neighboring gene Sin3A Neighboring gene long non-coding RNA:CR30055 Neighboring gene long non-coding RNA:CR45279 Neighboring gene Amphiphysin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells. Saha S, et al. Nat Nanotechnol, 2015 Jul. PMID 26098226
    2. Properties and possible function of a hyperpolarisation-activated chloride current in Drosophila. Rose U, et al. J Exp Biol, 2007 Jul. PMID 17601953
    3. Integrative physiology and functional genomics of epithelial function in a genetic model organism. Dow JT, et al. Physiol Rev, 2003 Jul. PMID 12843407
    4. Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Cabrero P, et al. Proc Natl Acad Sci U S A, 2014 Sep 30. PMID 25228763, Free PMC Article
    5. Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death. Mondragon AA, et al. Cell Rep, 2019 Apr 2. PMID 30943394, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloride transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloride channel-b
    Names
    CG8594-PA
    ClC-b-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12572068..12575299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136954.4 → NP_610798.1  chloride channel-b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZ25
      Related
      FBpp0086939
      Conserved Domains (4) summary
      COG0517
      Location:653 → 811
      CBS; CBS domain [Signal transduction mechanisms]
      cd03685
      Location:115 → 639
      ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
      cd04591
      Location:674 → 811
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:213 → 620
      Voltage_CLC; Voltage gated chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZ25 Q7JZ25

    Gene LinkOut

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