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    Slc52a2 solute carrier family 52 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362942, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc52a2provided by RGD
    Official Full Name
    solute carrier family 52 member 2provided by RGD
    Primary source
    RGD:1560410
    See related
    EnsemblRapid:ENSRNOG00000032561 AllianceGenome:RGD:1560410
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rRFT1; Gpr172a; Gpr172b; RGD1560410
    Summary
    Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 50.5), Adrenal (RPKM 33.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc52a2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110126632..110146647)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108246003..108267642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117605038..117608460)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene scratch family transcriptional repressor 1 Neighboring gene transfer RNA proline (anticodon AGG) 52 Neighboring gene transmembrane protein 249 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene uncharacterized LOC134479929 Neighboring gene uncharacterized LOC134479928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier. Kubo Y, et al. Drug Metab Pharmacokinet, 2019 Dec. PMID 31601465
    2. Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier. Kubo Y, et al. Drug Metab Pharmacokinet, 2017 Feb. PMID 27964953
    3. SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters. Udhayabanu T, et al. Clin Chim Acta, 2016 Nov 1. PMID 27702554, Free PMC Article
    4. Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Yonezawa A, et al. Am J Physiol Cell Physiol, 2008 Sep. PMID 18632736
    5. Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain. Andriamampandry C, et al. FASEB J, 2007 Mar. PMID 17197387

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The obtained results suggested the involvement of riboflavin transporters (SLC52A/RFVT) at the outer BRB, and this is supported by the expression and knockdown analyses of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3).
      Title: Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier.
    2. The function and inhibition profile suggested the involvement of riboflavin transporter 2 in riboflavin transport at the inner BRB, and this is supported by expression and knockdown analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells.
      Title: Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.
    3. Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3.
      Title: Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine.
    4. Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter.
      Title: Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-hydroxybutyrate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-hydroxybutyrate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in flavin adenine dinucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in riboflavin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 52, riboflavin transporter, member 2
    Names
    G protein-coupled receptor 172A
    G protein-coupled receptor 172B
    porcine endogenous retrovirus A receptor 2
    riboflavin transporter 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109670.1 → NP_001103140.1  solute carrier family 52, riboflavin transporter, member 2

      See identical proteins and their annotated locations for NP_001103140.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/Swiss-Prot
      A3KN99, B5MEV3
      Conserved Domains (1) summary
      pfam06237
      Location:278 → 375
      DUF1011; Protein of unknown function (DUF1011)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110126632..110146647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263875.1 → XP_063119945.1  solute carrier family 52, riboflavin transporter, member 2 isoform X2

      UniProtKB/Swiss-Prot
      A3KN99, B5MEV3

    2. XM_039079554.2 → XP_038935482.1  solute carrier family 52, riboflavin transporter, member 2 isoform X2

      UniProtKB/Swiss-Prot
      A3KN99, B5MEV3
      Conserved Domains (1) summary
      pfam06237
      Location:278 → 375
      DUF1011; Protein of unknown function (DUF1011)

    3. XM_006241826.5 → XP_006241888.1  solute carrier family 52, riboflavin transporter, member 2 isoform X2

      See identical proteins and their annotated locations for XP_006241888.1

      UniProtKB/Swiss-Prot
      A3KN99, B5MEV3
      Related
      ENSRNOP00000046721.3, ENSRNOT00000047380.6
      Conserved Domains (1) summary
      pfam06237
      Location:278 → 375
      DUF1011; Protein of unknown function (DUF1011)

    4. XM_063263874.1 → XP_063119944.1  solute carrier family 52, riboflavin transporter, member 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5MEV3.2 GenPept UniProtKB/Swiss-Prot:B5MEV3

    Gene LinkOut

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