Bicd1 BICD cargo adaptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bicd1provided by RGD
Official Full Name: BICD cargo adaptor 1provided by RGD
Primary source: RGD:1309444
See related: EnsemblRapid:ENSRNOG00000036911 AllianceGenome:RGD:1309444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables proteinase activated receptor binding activity. Involved in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be active in Golgi apparatus and cytosol. Predicted to colocalize with cytoplasmic microtubule. Orthologous to human BICD1 (BICD cargo adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 139.2), Adrenal (RPKM 35.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (184208891..184362840)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (182479071..182631504)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (184018845..184167628)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization
Title: A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:225109 (e-PCR)
- UniSTS:225109

BI303473 (e-PCR)
- UniSTS:248239

d2mgh14 (e-PCR)
- UniSTS:121589

AI325948 (e-PCR)
- UniSTS:179455

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal anchor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal anchor activity	ISO Inferred from Sequence Orthology more info
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynactin binding	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables proteinase activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteinase activated receptor binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule anchoring at microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule anchoring at microtubule organizing center	ISO Inferred from Sequence Orthology more info
involved_in minus-end-directed organelle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteinase activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in viral process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein bicaudal D homolog 1

Names: bicaudal D homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108653.1 → NP_001102123.1 protein bicaudal D homolog 1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6IN76

Related

ENSRNOP00000052303.4, ENSRNOT00000055435.4

Conserved Domains (1) summary

pfam09730
Location:74 → 799

BicD; Microtubule-associated protein Bicaudal-D

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

184208891..184362840

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237703.5 → XP_006237765.1 protein bicaudal D homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZKI9

Related

ENSRNOP00000107545.1, ENSRNOT00000140676.1

Conserved Domains (1) summary

pfam09730
Location:74 → 799

BicD; Microtubule-associated protein Bicaudal-D
XM_017592727.3 → XP_017448216.1 protein bicaudal D homolog 1 isoform X2
XM_063286385.1 → XP_063142455.1 protein bicaudal D homolog 1 isoform X3
XM_039107954.2 → XP_038963882.1 protein bicaudal D homolog 1 isoform X4

UniProtKB/TrEMBL

D4ADZ2

Conserved Domains (1) summary

pfam09730
Location:74 → 799

BicD; Microtubule-associated protein Bicaudal-D
XM_006237706.5 → XP_006237768.1 protein bicaudal D homolog 1 isoform X6

UniProtKB/TrEMBL

A0A8I6A0G7

Conserved Domains (1) summary

pfam09730
Location:74 → 799

BicD; Microtubule-associated protein Bicaudal-D
XM_006237705.5 → XP_006237767.1 protein bicaudal D homolog 1 isoform X5

Conserved Domains (1) summary

pfam09730
Location:74 → 799

BicD; Microtubule-associated protein Bicaudal-D