Cstf3 cleavage stimulation factor subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cstf3provided by RGD
Official Full Name: cleavage stimulation factor subunit 3provided by RGD
Primary source: RGD:1305901
See related: EnsemblRapid:ENSRNOG00000012089 AllianceGenome:RGD:1305901
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage stimulating factor complex. Predicted to be active in nucleus. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Thymus (RPKM 99.3), Spleen (RPKM 70.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (111421291..111492539)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (90966415..91037669)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (94530586..94603378)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139617 (e-PCR)
- UniSTS:221701

RH140475 (e-PCR)
- UniSTS:221701

RH126683 (e-PCR)
- UniSTS:207371

BF406428 (e-PCR)
- UniSTS:248363

RH144362 (e-PCR)
- UniSTS:233607

RH142661 (e-PCR)
- UniSTS:231908

D3Got46 (e-PCR)
- UniSTS:114429

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of mRNA cleavage stimulating factor complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cleavage stimulation factor subunit 3

Names: cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077672.1 → NP_001071140.1 cleavage stimulation factor subunit 3

See identical proteins and their annotated locations for NP_001071140.1

Status: PROVISIONAL

Source sequence(s)

BC127520

UniProtKB/TrEMBL

A0A096MJQ0, A0JPN7

Related

ENSRNOP00000068217.2, ENSRNOT00000076762.3

Conserved Domains (3) summary

smart00386
Location:45 → 77

HAT; HAT (Half-A-TPR) repeats

COG5107
Location:2 → 532

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

pfam05843
Location:375 → 548

Suf; Suppressor of forked protein (Suf)