Gtf3c5 general transcription factor IIIC subunit 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gtf3c5provided by RGD
Official Full Name: general transcription factor IIIC subunit 5provided by RGD
Primary source: RGD:1305173
See related: EnsemblRapid:ENSRNOG00000010981 AllianceGenome:RGD:1305173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase III general transcription initiation factor activity. Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 49.1), Lung (RPKM 48.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (32291851..32312188, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (11893867..11914187, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (7144354..7164678, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase III general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIIC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: general transcription factor 3C polypeptide 5

Names: general transcription factor IIIC, polypeptide 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079941.1 → NP_001073410.1 general transcription factor 3C polypeptide 5

See identical proteins and their annotated locations for NP_001073410.1

Status: PROVISIONAL

Source sequence(s)

BC129109

UniProtKB/TrEMBL

A1L1K6

Related

ENSRNOP00000015068.4, ENSRNOT00000015068.8

Conserved Domains (1) summary

pfam09734
Location:24 → 322

Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

32291851..32312188 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233835.5 → XP_006233897.1 general transcription factor 3C polypeptide 5 isoform X1

Conserved Domains (1) summary

pfam09734
Location:24 → 322

Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
XM_039105367.2 → XP_038961295.1 general transcription factor 3C polypeptide 5 isoform X2

UniProtKB/TrEMBL

A6JTP2

Conserved Domains (1) summary

pfam09734
Location:43 → 197

Tau95; RNA polymerase III transcription factor (TF)IIIC subunit