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    Ccp110 centriolar coiled-coil protein 110 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361634, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ccp110provided by RGD
    Official Full Name
    centriolar coiled-coil protein 110provided by RGD
    Primary source
    RGD:1310509
    See related
    EnsemblRapid:ENSRNOG00000027405 AllianceGenome:RGD:1310509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cp110; RGD1310509
    Summary
    Predicted to be involved in microtubule organizing center organization; regulation of cell cycle process; and regulation of cilium assembly. Predicted to be located in centrosome. Predicted to be part of protein-containing complex. Predicted to be active in centriole. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 175.1), Testes (RPKM 131.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccp110 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182475571..182504235)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173042238..173072873)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188417012..188444991)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099917 Neighboring gene transmembrane channel-like 5 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene small nucleolar RNA SNORA24 Neighboring gene lysine-rich nucleolar protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Polo kinase Plk4 functions in centriole duplication. Habedanck R, et al. Nat Cell Biol, 2005 Nov. PMID 16244668
    2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Chen Z, et al. Dev Cell, 2002 Sep. PMID 12361598
    3. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Li J, et al. Nature, 2013 Mar 14. PMID 23486064, Free PMC Article
    4. Cep97 and CP110 suppress a cilia assembly program. Spektor A, et al. Cell, 2007 Aug 24. PMID 17719545
    5. Plk4-induced centriole biogenesis in human cells. Kleylein-Sohn J, et al. Dev Cell, 2007 Aug. PMID 17681131

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ciliary basal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ciliary basal body organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centriolar coiled-coil protein of 110 kDa
    Names
    centriolar coiled coil protein 110kDa
    centrosomal protein of 110 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108501.1 → NP_001101971.1  centriolar coiled-coil protein of 110 kDa

      See identical proteins and their annotated locations for NP_001101971.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I5ZNZ6, A6I8I5, D4A3J9
      Related
      ENSRNOP00000082093.2, ENSRNOT00000114744.2
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      182475571..182504235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082809.2 → XP_038938737.1  centriolar coiled-coil protein of 110 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNZ6, A6I8I5, D4A3J9
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    2. XM_063267558.1 → XP_063123628.1  centriolar coiled-coil protein of 110 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I6GDT4, A6I8I4, A6I8I6

    3. XM_063267560.1 → XP_063123630.1  centriolar coiled-coil protein of 110 kDa isoform X4

      UniProtKB/TrEMBL
      A6I8I6

    4. XM_039082822.2 → XP_038938750.1  centriolar coiled-coil protein of 110 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I6GDT4, A6I8I4, A6I8I6
      Related
      ENSRNOP00000035030.7, ENSRNOT00000037870.8
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    5. XM_039082825.2 → XP_038938753.1  centriolar coiled-coil protein of 110 kDa isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZJN5, A6I8I6
      Related
      ENSRNOP00000078065.1, ENSRNOT00000111681.2
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    6. XM_039082821.2 → XP_038938749.1  centriolar coiled-coil protein of 110 kDa isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNZ6
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    7. XM_063267559.1 → XP_063123629.1  centriolar coiled-coil protein of 110 kDa isoform X4

      UniProtKB/TrEMBL
      A6I8I6

    8. XM_063267568.1 → XP_063123638.1  centriolar coiled-coil protein of 110 kDa isoform X6

      UniProtKB/TrEMBL
      A6I8I6

    9. XM_039082813.2 → XP_038938741.1  centriolar coiled-coil protein of 110 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNZ6, A6I8I5, D4A3J9
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    10. XM_039082811.2 → XP_038938739.1  centriolar coiled-coil protein of 110 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNZ6, A6I8I5, D4A3J9
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    11. XM_063267557.1 → XP_063123627.1  centriolar coiled-coil protein of 110 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I6GDT4, A6I8I4, A6I8I6

    12. XM_063267544.1 → XP_063123614.1  centriolar coiled-coil protein of 110 kDa isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNZ6

    13. XM_039082816.2 → XP_038938744.1  centriolar coiled-coil protein of 110 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNZ6, A6I8I5, D4A3J9
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    14. XM_039082814.2 → XP_038938742.1  centriolar coiled-coil protein of 110 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNZ6, A6I8I5, D4A3J9
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding
    Nucleotide Protein Strain
    Heading Accession and Version

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