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    Brd7 bromodomain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Brd7provided by RGD
    Official Full Name
    bromodomain containing 7provided by RGD
    Primary source
    RGD:1309891
    See related
    EnsemblRapid:ENSRNOG00000014419 AllianceGenome:RGD:1309891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including lysine-acetylated histone binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 197.7), Spleen (RPKM 165.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brd7 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (34882238..34910944)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (18708792..18737497)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (19672780..19701484)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483298 Neighboring gene NKD inhibitor of WNT signaling pathway 1 Neighboring gene uncharacterized LOC134483621 Neighboring gene uncharacterized LOC120098503 Neighboring gene adenylate cyclase 7 Neighboring gene uncharacterized LOC134483299 Neighboring gene terminal nucleotidyltransferase 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prognostic relevance of BRD7 expression in colorectal carcinoma. Wu WJ, et al. Eur J Clin Invest, 2013 Feb. PMID 23215825
    2. Tumor suppressive effects of bromodomain-containing protein 7 (BRD7) in epithelial ovarian carcinoma. Park YA, et al. Clin Cancer Res, 2014 Feb 1. PMID 24198243
    3. [Expression and clinical significance of bromodomain-containing protein 7 in non-small cell lung cancer]. Chen L, et al. Zhongguo Fei Ai Za Zhi, 2011 Oct. PMID 22008115, Free PMC Article
    4. [Expression and SNP analysis of BRD7 gene in acute leukemia cells]. Tang XY, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2008 Aug. PMID 18772500
    5. BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway. Wang XM, et al. J Cell Mol Med, 2017 Jun. PMID 27957794, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401242.1 → NP_001388171.1  bromodomain-containing protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    2. NM_001401243.1 → NP_001388172.1  bromodomain-containing protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2JTM7
      Related
      ENSRNOP00000068771.1, ENSRNOT00000086560.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      34882238..34910944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097814.2 → XP_038953742.1  bromodomain-containing protein 7 isoform X2

      Conserved Domains (2) summary
      cd05513
      Location:135 → 232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:310 → 485
      DUF3512; Domain of unknown function (DUF3512)

    2. XM_039097812.2 → XP_038953740.1  bromodomain-containing protein 7 isoform X1

      Conserved Domains (2) summary
      cd05513
      Location:135 → 232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:310 → 485
      DUF3512; Domain of unknown function (DUF3512)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108440.1: Suppressed sequence

      Description
      NM_001108440.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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