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    Cog3 component of oligomeric golgi complex 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361073, updated on 2-Nov-2024

    Summary

    Official Symbol
    Cog3provided by RGD
    Official Full Name
    component of oligomeric golgi complex 3provided by RGD
    Primary source
    RGD:1304555
    See related
    EnsemblRapid:ENSRNOG00000000155 AllianceGenome:RGD:1304555
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including Golgi vesicle transport; protein glycosylation; and protein stabilization. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 99.4), Adrenal (RPKM 98.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cog3 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (57389994..57480454, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (51020808..51071288, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (57753814..57805627, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 13 Neighboring gene uncharacterized LOC120097040 Neighboring gene siah E3 ubiquitin protein ligase family member 3 Neighboring gene chibby family member 2 Neighboring gene GABA type A receptor associated protein like 2, pseudogene 2 Neighboring gene glutamate-rich 6B Neighboring gene solute carrier family 25, member 30 Neighboring gene uncharacterized LOC102552389

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012157.1NP_001012157.1  conserved oligomeric Golgi complex subunit 3

      See identical proteins and their annotated locations for NP_001012157.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083901
      UniProtKB/TrEMBL
      A0A8I6ABS2, F1LLY2, Q5XHZ8
      Related
      ENSRNOP00000000168.7, ENSRNOT00000000168.8
      Conserved Domains (1) summary
      pfam04136
      Location:131274
      Sec34; Sec34-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      57389994..57480454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274435.1XP_063130505.1  conserved oligomeric Golgi complex subunit 3 isoform X2

      Related
      ENSRNOP00000103916.1, ENSRNOT00000158343.1
    2. XM_063274434.1XP_063130504.1  conserved oligomeric Golgi complex subunit 3 isoform X1

      Related
      ENSRNOP00000090801.1, ENSRNOT00000093907.2
    3. XM_063274437.1XP_063130507.1  conserved oligomeric Golgi complex subunit 3 isoform X3