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    Cip2a cellular inhibitor of PP2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360711, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cip2aprovided by RGD
    Official Full Name
    cellular inhibitor of PP2Aprovided by RGD
    Primary source
    RGD:1310335
    See related
    EnsemblRapid:ENSRNOG00000039183 AllianceGenome:RGD:1310335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310335
    Summary
    Predicted to enable protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Predicted to be located in cytosol and plasma membrane. Orthologous to human CIP2A (cellular inhibitor of PP2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 50.7), Spleen (RPKM 35.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (65255123..65285914, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (51792143..51823016, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (54373794..54404704, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leukocyte surface antigen CD47-like Neighboring gene myosin, heavy chain 15 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene resistin-like gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. Ventelä S, et al. PLoS One, 2012. PMID 22461891, Free PMC Article
    2. CIP2A increases self-renewal and is linked to Myc in neural progenitor cells. Kerosuo L, et al. Differentiation, 2010 Jul. PMID 20447748
    3. Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. Wang J, et al. EMBO Rep, 2017 Mar. PMID 28174209, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in broken chromosome clustering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in broken chromosome clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein CIP2A
    Names
    cell proliferation regulating inhibitor of protein phosphatase 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427687.2 → NP_001414616.1  protein CIP2A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I5ZXN3, D3ZF50
      Related
      ENSRNOP00000031394.4, ENSRNOT00000033837.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      65255123..65285914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088875.2 → XP_038944803.1  protein CIP2A isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:302 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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