egr eiger [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: egrprovided by FlyBase
Official Full Name: eigerprovided by FlyBase
Primary source: FLYBASE:FBgn0033483
Locus tag: Dmel_CG12919
See related: AllianceGenome:FB:FBgn0033483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH51659; CG12919; darth; Dmel\CG12919; dt1; Ect1; Egr; EGR; Eig; Eiger; regg1; Regg1; TNF; TNF-alpha; TNFalpha
Summary: Enables receptor ligand activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including apical protein localization; asymmetric protein localization involved in cell fate determination; and defense response to other organism. Acts upstream of with a positive effect on apoptotic process. Is active in extracellular space and plasma membrane. Is expressed in several structures, including ectoderm; ectoderm anlage; embryonic head epidermis; embryonic/larval peripheral nervous system; and extended germ band embryo. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; ectodermal dysplasia 1; and tooth agenesis. Orthologous to several human genes including EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 46E1-46E3; 2-62 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10078366..10084210)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5965871..5971715)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Title: Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Deltex cooperates with TRAF6 to promote apoptosis and cell migration through Eiger-independent JNK activation in Drosophila.
Title: Deltex cooperates with TRAF6 to promote apoptosis and cell migration through Eiger-independent JNK activation in Drosophila.
Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Title: Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis.
Title: Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis.
such Egr-induced necrosis depends on the catalytic activity of the initiator caspase Dronc and the input from JNK signaling but is independent of their roles in apoptosis. Further mosaic analysis with mutants of scribble (scrib), suggests that Egr/JNK-mediated apoptosis and necrosis establish a two-layered defense system to inhibit the oncogenic growth of scrib mutant cells
Title: Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.
These results reveal that Tumour Necrosis Factor mediates exposure of phosphatidylserine (PS), which makes tumor cells selectively sensitive to the action of Defensin remotely secreted from tracheal and fat tissues.
Title: The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila.
Activation of Dmp53 in the growth-depleted territory induces the expression of the Eiger, which activates the JNK stress signaling pathway. JNK-dependent expression of the systemic hormone dILP8 reduces the growth and final size of adjacent territories, the production of Reactive Oxygen Species downstream of JNK and the apoptotic machinery act locally to regulate the proliferation of adjacent epithelial cells.
Title: Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila.
Autocrine activation of the adenosine receptor leads to transcriptional upregulation of TNF, which in turn boosts the activity of JNK signalling.
Title: Epithelial cells release adenosine to promote local TNF production in response to polarity disruption.
Activation of epidermal Dronc induces TNF-dependent but effector caspase-independent nociceptive sensitization in the absence of UV. In addition, knockdown of Dronc attenuated nociceptive sensitization induced by full-length TNF/Eiger but not by a constitutively soluble form. UV irradiation induced TNF production in both in vitro and in vivo
Title: Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization.
This study shows that Eiger, the Drosophila TNF-alpha, is a metabolic hormone that mediates nutrient response by remotely acting on insulin-producing cells.
Title: The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor superfamily binding	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor superfamily binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables tumor necrosis factor receptor superfamily binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to tumor cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eiger

Names: CG12919-PA; CG12919-PB; Eiger, tumour necrosis factor family member; TNF-alpha; drosophila aspartate rich TNF homolog; egr-PA; egr-PB; tumor necrosis factor family member DT1; wengen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

10078366..10084210

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165735.4 → NP_724878.2 eiger, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724878.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IGD3, Q8MRW2, Q8MUJ1, Q8MY88

Related

FBpp0087493

Conserved Domains (1) summary

cd00184
Location:278 → 413

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_206069.3 → NP_995791.1 eiger, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995791.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MUJ1

Conserved Domains (1) summary

cd00184
Location:272 → 407

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...