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    Pka-R2 Protein kinase, cAMP-dependent, regulatory subunit type 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Pka-R2provided by FlyBase
    Official Full Name
    Protein kinase, cAMP-dependent, regulatory subunit type 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0022382
    Locus tag
    Dmel_CG15862
    See related
    AllianceGenome:FB:FBgn0022382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM01761; CG15862; Cos; Cos-1; cos1; Cos1; Dmel\CG15862; Epa; pkA; PKA; PKA R2; pka RII; PKA RII; PKa-R2; PKA-R2; pka-RII; Pka-RII; PKA-RII; PKAR2; RII; RII[[DR]]
    Summary
    Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in several processes, including behavioral response to cocaine; locomotor rhythm; and response to ethanol. Located in cytoplasm. Is expressed in several structures, including embryonic/larval fat body; gut section; medulla; mushroom body; and ventral midline of embryo. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to several human genes including PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Pka-R2 in Genome Data Viewer
    Location:
    46D1-46D4; 2-61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9993890..10026042, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5881395..5913547, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43948 Neighboring gene even skipped Neighboring gene long non-coding RNA:CR45324 Neighboring gene Transitional endoplasmic reticulum 94 Neighboring gene mir-4967 stem loop Neighboring gene long non-coding RNA:CR44294 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling at A-kinase anchoring proteins organizes anesthesia-sensitive memory in Drosophila. Schwaerzel M, et al. J Neurosci, 2007 Jan 31. PMID 17267579, Free PMC Article
    2. Purification of a regulatory subunit of type II cAMP-dependent protein kinase from Drosophila heads. Inoue H, et al. Biochem Biophys Res Commun, 1997 Jun 9. PMID 9196067
    3. Drosophila cAMP-dependent protein kinase. Foster JL, et al. J Biol Chem, 1984 Nov 10. PMID 6436241
    4. Type II cAMP-dependent protein kinase-deficient Drosophila are viable but show developmental, circadian, and drug response phenotypes. Park SK, et al. J Biol Chem, 2000 Jul 7. PMID 10781603
    5. Characterization of the targeting, binding, and phosphorylation site domains of an A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog that are encoded by a single gene. Rossi EA, et al. J Biol Chem, 1999 Sep 17. PMID 10480937

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alleles of Cos1 appear to be dominant-negative mutations of a catalytic subunit of protein kinase A
      Title: Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c10012242-10012172 mobile_element_type = transposon:INE-1{}3685
    • Loc: c10022989-10022578 mobile_element_type = transposon:FB{}3466

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to cocaine NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in behavioral response to ethanol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhythmic behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cAMP-dependent protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    protein kinase, cAMP-dependent, regulatory subunit type 2
    Names
    CG15862-PA
    CG15862-PB
    CG15862-PD
    CG15862-PE
    Costal-1
    Pka-R2-PA
    Pka-R2-PB
    Pka-R2-PD
    Pka-R2-PE
    cAMP-dependent protein kinase R2
    cAMP-dependent protein kinase type II
    costal
    epaulette
    protein kinase A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9993890..10026042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165723.4 → NP_724860.2  protein kinase, cAMP-dependent, regulatory subunit type 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724860.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1A6P8, A1A6T9, A2RVH2, A4UZA6, A8DY87, A8DY88, P81900, Q9NB18, Q9V5E8
      Related
      FBpp0087524
      Conserved Domains (2) summary
      cd12099
      Location:11 → 49
      DD_RII_PKA; Dimerization/Docking domain of the Type II Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:124 → 233
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. NM_078947.4 → NP_523671.1  protein kinase, cAMP-dependent, regulatory subunit type 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1A6P8, A1A6T9, A2RVH2, A4UZA6, A8DY87, A8DY88, P81900, Q9NB18, Q9V5E8
      Related
      FBpp0087523
      Conserved Domains (2) summary
      cd12099
      Location:11 → 49
      DD_RII_PKA; Dimerization/Docking domain of the Type II Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:124 → 233
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    3. NM_001103781.3 → NP_001097251.1  protein kinase, cAMP-dependent, regulatory subunit type 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81900
      Conserved Domains (2) summary
      cd12099
      Location:11 → 49
      DD_RII_PKA; Dimerization/Docking domain of the Type II Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:124 → 233
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    4. NM_001103782.2 → NP_001097252.1  protein kinase, cAMP-dependent, regulatory subunit type 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097252.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81900
      Conserved Domains (2) summary
      cd12099
      Location:11 → 49
      DD_RII_PKA; Dimerization/Docking domain of the Type II Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:124 → 233
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81900.2 P81900
    Q95SE3 Q95SE3

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