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    babo baboon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35900, updated on 2-Nov-2024

    Summary

    Official Symbol
    baboprovided by FlyBase
    Official Full Name
    baboonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011300
    Locus tag
    Dmel_CG8224
    See related
    AllianceGenome:FB:FBgn0011300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Atf1; Atr-1; ATR-1; atr-I; Atr-I; ATR-I; Atr45A; AtrI; Bab; Babo; BABO; BaboA; Baboon; CG8224; Dmel\CG8224; Gprk-3; Gprk3; l(2)44Fd; l(2)k16912; STK-E
    Summary
    Enables activin binding activity and activin receptor activity, type I. Involved in several processes, including determination of adult lifespan; imaginal disc morphogenesis; and nervous system development. Located in plasma membrane. Part of activin receptor complex. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval gut; female germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); gastrointestinal system cancer (multiple); and malignant mesothelioma. Orthologous to human ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See babo in Genome Data Viewer
    Location:
    44F11-44F12; 2-59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8952339..8962796)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4839844..4850301)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Translocase of outer membrane 7 Neighboring gene space blanket Neighboring gene filzig

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables activin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables activin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables activin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables activin receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables activin receptor activity, type I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables activin receptor activity, type I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_positive_effect determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye-antennal disc morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of activin receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    baboon
    Names
    CG8224-PA
    CG8224-PB
    CG8224-PC
    G protein-coupled receptor kinase 3
    activin A receptor 45A
    activin type I receptor
    babo
    babo-PA
    babo-PB
    babo-PC
    baboa
    NP_001163092.1
    NP_476999.1
    NP_477000.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8952339..8962796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057651.4NP_476999.1  baboon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7L8, Q23975
      Related
      FBpp0087739
      Conserved Domains (4) summary
      smart00467
      Location:294324
      GS; GS motif
      cd14143
      Location:328615
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:127214
      Activin_recp; Activin types I and II receptor domain
      pfam07714
      Location:324611
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_057652.4NP_477000.1  baboon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7L9, Q23975
      Related
      FBpp0087740
      Conserved Domains (4) summary
      smart00467
      Location:273303
      GS; GS motif
      cd14143
      Location:307594
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:127204
      Activin_recp; Activin types I and II receptor domain
      pfam07714
      Location:303590
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_001169621.2NP_001163092.1  baboon, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23975, Q7YU60
      Conserved Domains (4) summary
      smart00467
      Location:267297
      GS; GS motif
      cd14143
      Location:301588
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:127196
      Activin_recp; Activin types I and II receptor domain
      pfam07714
      Location:297584
      Pkinase_Tyr; Protein tyrosine kinase