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    Cyp4e2 Cytochrome P450 4e2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35822, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cyp4e2provided by FlyBase
    Official Full Name
    Cytochrome P450 4e2provided by FlyBase
    Primary source
    FLYBASE:FBgn0014469
    Locus tag
    Dmel_CG2060
    See related
    AllianceGenome:FB:FBgn0014469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4e2; CG2060; cyp4e2; Cyp4E2; CyP4e2; CYP4E2; Cyt-P450-4E2; Dmel\CG2060; P-450; P450
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; epithelium; and yolk nucleus. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cyp4e2 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8444560..8447164)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4332065..4334669)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 4 Neighboring gene Cytochrome P450 4ad1 Neighboring gene mir-986 stem loop Neighboring gene Cytochrome P450 4e1 Neighboring gene Maltase A1 Neighboring gene Maltase A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of a Drosophila Cyp4e2 cytochrome P450-encoding cDNA. Pittendrigh BR, et al. Gene, 1996 Nov 14. PMID 8972915
    2. Inhalation toxicity of indoor air pollutants in Drosophila melanogaster using integrated transcriptomics and computational behavior analyses. Eom HJ, et al. Sci Rep, 2017 Jun 16. PMID 28621308, Free PMC Article
    3. Cytochrome P450 monooxygenases and insecticide resistance in insects. Bergé JB, et al. Philos Trans R Soc Lond B Biol Sci, 1998 Oct 29. PMID 10021770, Free PMC Article
    4. Sleep and the fruit fly. Greenspan RJ, et al. Trends Neurosci, 2001 Mar. PMID 11182453
    5. Correlates of sleep and waking in Drosophila melanogaster. Shaw PJ, et al. Science, 2000 Mar 10. PMID 10710313

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 4e2
    Names
    CG2060-PA
    CG2060-PB
    Cyp4e2-PA
    Cyp4e2-PB
    cytochrome P450
    cytochrome P450-4e2
    NP_001286196.1
    NP_477117.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8444560..8447164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299267.1 → NP_001286196.1  cytochrome P450 4e2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24130, Q24291, Q27606, Q9V4T4
      UniProtKB/TrEMBL
      A0A0B4LFT2
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 469
      p450; Cytochrome P450

    2. NM_057769.4 → NP_477117.2  cytochrome P450 4e2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477117.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24130, Q24291, Q27606, Q9V4T4
      UniProtKB/TrEMBL
      A0A0B4LFT2
      Related
      FBpp0087824
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 469
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFT2 A0A0B4LFT2
    Q27606.2 Q27606

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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