BicD Bicaudal D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BicDprovided by FlyBase
Official Full Name: Bicaudal Dprovided by FlyBase
Primary source: FLYBASE:FBgn0000183
Locus tag: Dmel_CG6605
See related: AllianceGenome:FB:FBgn0000183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe2A11; Bic-D; BIC-D; bicD; BICD; Bic[D]; CG6605; Dmel\CG6605
Summary: Enables clathrin heavy chain binding activity and small GTPase binding activity. Involved in several processes, including mRNA transport; oocyte differentiation; and regulation of vesicle-mediated transport. Located in cytoplasm. Colocalizes with clathrin-coated endocytic vesicle membrane. Is expressed in several structures, including embryonic/larval tracheal system; extended germ band embryo; head; ovary; and presumptive embryonic/larval system. Used to study spinal muscular atrophy with lower extremity predominance 2A. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominance 2A and spinal muscular atrophy with lower extremity predominante 2B. Orthologous to human BICD1 (BICD cargo adaptor 1) and BICD2 (BICD cargo adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 36C9-36C9; 2-53 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (17459605..17473215, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (17459605..17473215, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of BicDR in bristle shaft construction and support of BicD functions.
Title: Role of BicDR in bristle shaft construction and support of BicD functions.
Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility.
Title: Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility.
the RNA is required for robust activation of dynein motility. We show that a cis-acting RNA localisation signal promotes the interaction of Egl with BicD, which licenses the latter protein to recruit dynein and dynactin. Our data support a model for BicD activation based on RNA-induced occupancy of two Egl-binding sites on the BicD dimer.
Title: RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs.
artificially dimerized Egl activates dynein-dynactin-BicD in the absence of mRNA. The ability of mRNA cargo to orchestrate the activation of the mRNP (messenger ribonucleotide protein) complex is an elegant way to ensure that only cargo-bound motors are motile.
Title: Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex.
To study the pathological consequences of BICD2 mutations in vivo, and to address the controversial debate whether two of these mutations are neuron or muscle specific, we generated the first Drosophila model of spinal muscular atrophy-2.
Title: Novel insights into SMALED2: BICD2 mutations increase microtubule stability and cause defects in axonal and NMJ development.
Bic-D is also required to transport Chc mRNA into the oocyte and for transport and proper localization of Chc protein to the oocyte cortex.
Title: Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D.
2.2 A resolution crystal structure of a cargo-binding region of the dynein adaptor Bicaudal-D (BicD), which reveals a parallel coiled-coil homodimer
Title: Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.
Results implicate BicD as a new player in clathrin-associated trafficking processes and show a novel requirement for microtubule-based motor transport in the synaptic vesicle cycle.
Title: Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
while BicD might contribute to recruitment of dynein to the cargo it is not absolutely required for such dynein localization
Title: BicaudalD actively regulates microtubule motor activity in lipid droplet transport.
We propose that Msn functions together with Bic-D to regulate the apical localization of dynein in generating directed nuclear migration within differentiating R-cell precursor cells.
Title: The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cargo adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables clathrin heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal anchor activity	IEA Inferred from Electronic Annotation more info
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
NOT enables mRNA binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular macromolecule localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring at microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte axis specification	TAS Traceable Author Statement more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	HMP more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to organelle	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with clathrin-coated endocytic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bicaudal D

Names: BicD-PA; BicD-PB; BicD-PC; BicD-PD; Bicaudal-D; BicaudalD; Bicuadal-D; CG6605-PA; CG6605-PB; CG6605-PC; CG6605-PD; almond; anon-fast-evolving-2A11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

17459605..17473215 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273601.1 → NP_001260530.1 bicaudal D, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260530.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16568, Q9VJD5

UniProtKB/TrEMBL

M9PDL9

Conserved Domains (1) summary

pfam09730
Location:80 → 742

BicD; Microtubule-associated protein Bicaudal-D
NM_165220.3 → NP_724056.1 bicaudal D, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724056.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16568, Q9VJD5

UniProtKB/TrEMBL

M9PDL9

Related

FBpp0080555

Conserved Domains (1) summary

pfam09730
Location:80 → 742

BicD; Microtubule-associated protein Bicaudal-D
NM_001273602.1 → NP_001260531.1 bicaudal D, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260531.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDB8

Conserved Domains (1) summary

pfam09730
Location:80 → 742

BicD; Microtubule-associated protein Bicaudal-D
NM_001259128.2 → NP_001246057.1 bicaudal D, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246057.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDR2

Conserved Domains (1) summary

pfam09730
Location:80 → 742

BicD; Microtubule-associated protein Bicaudal-D