grp grapes [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: grpprovided by FlyBase
Official Full Name: grapesprovided by FlyBase
Primary source: FLYBASE:FBgn0261278
Locus tag: Dmel_CG17161
See related: AllianceGenome:FB:FBgn0261278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1C; CG17161; chk1; Chk1; CHK1; CHK1/Grapes; dChk1; Dchk1; DmChk1; Dmel\CG17161; grapes; Grp; grp(chk); Grp/DChk1; grps; l(2)k15102; lemp; Pk36A; Pk?1
Summary: Enables protein kinase activity. Involved in several processes, including DNA integrity checkpoint signaling; microtubule cytoskeleton organization; and regulation of syncytial blastoderm mitotic cell cycle. Located in nucleus. Is expressed in adult brain; adult mushroom body; oocyte; organism; and primordial germ cell. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 36A10-36A10; 2-52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16680054..16699926)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16680054..16699926)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
Title: Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.
Title: Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.
The authors propose that ATR/Chk1 negatively regulate G2-M in developing tracheoblasts and that G2 arrest facilitates cellular and hypertrophic organ growth.
Title: Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila.
Grp was assumed to play a direct role in the immune response in D. melanogaster.
Title: [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome].
The Grp gene is expressed at the adult stage of D. melanogaster in gender-specific and tissue-specific manner.
Title: Domesticated retroviral GAG gene in Drosophila: new functions for an old gene.
Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
Title: Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
The Grp gene has been demonstrated to be a functional gene in the D. melanogaster genome, bit its function is yet to be determined.
Title: [Translational analysis of the Grp gene, a genomic homologue of the Gag gene of the gypsy retrotransposon of Drosophila melanogaster].
the Grp gene is not a pseudogene, but it is a functional gene of the D. melanogaster genome whose role remains to be elucidated.
Title: [Transcriptional analysis of the Grp gene, a genomic homolog of the retrotransposon gypsy gag gene, in Drosophila melanogaster].
A genetic screen identified grapes, the gene that encodes the Drosophila orthologue of checkpoint kinase 1 (CHK1). Knockdown of grapes by RNAi rescued eye development despite ongoing PERK activation.
Title: Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.
The Grp gene product has a highly conserved structure in different species of the Drosophilidae family and is under stabilizing selection, which suggests its important genomic function in Drosophila.
Title: [Molecular evolution of mobile elements of the gypsy group: a homolog of the gag gene in Drosophila].

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: grapes

Names: CG17161-PA; CG17161-PB; CG17161-PC; CG17161-PD; CG17161-PF; Chk1/Grapes; Grapes/Chk1; checkpoint kinase 1; grp-PA; grp-PB; grp-PC; grp-PD; grp-PF; last empress; lethal (2) k15102; protein kinase-like 36A

NP_001260508.1

EC 2.7.11.1

NP_477011.1

EC 2.7.11.1

NP_723985.1

EC 2.7.11.1

NP_723986.1

EC 2.7.11.1

NP_723987.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16680054..16699926

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165172.3 → NP_723986.1 grapes, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723986.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S9, O61661, Q960N7

Related

FBpp0080442

Conserved Domains (2) summary

smart00220
Location:22 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14069
Location:20 → 279

STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1
NM_165171.3 → NP_723985.1 grapes, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S9, O61661, Q960N7

Related

FBpp0080441

Conserved Domains (2) summary

smart00220
Location:22 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14069
Location:20 → 279

STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1
NM_001273579.1 → NP_001260508.1 grapes, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260508.1

Status: REVIEWED

UniProtKB/TrEMBL

Q59DY7

Conserved Domains (2) summary

smart00220
Location:1 → 164

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:1 → 165

PKc_like; Protein Kinases, catalytic domain
NM_057663.4 → NP_477011.1 grapes, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477011.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S9, O61661, Q960N7

Related

FBpp0080443

Conserved Domains (2) summary

smart00220
Location:22 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14069
Location:20 → 279

STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1
NM_165173.3 → NP_723987.2 grapes, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723987.2

Status: REVIEWED

UniProtKB/TrEMBL

Q59DY7

Conserved Domains (2) summary

smart00220
Location:1 → 164

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:1 → 165

PKc_like; Protein Kinases, catalytic domain