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    Idgf3 Imaginal disc growth factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34981, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Idgf3provided by FlyBase
    Official Full Name
    Imaginal disc growth factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0020414
    Locus tag
    Dmel_CG4559
    See related
    AllianceGenome:FB:FBgn0020414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS02780.2; CG4559; Dmel\CG4559; DmIDGF3; FBgn0020414; IDGF; IDGF-3; idgf3; IDGF3; lincRNA.163
    Summary
    Enables imaginal disc growth factor receptor binding activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and wound healing. Located in extracellular region. Is expressed in several structures, including circulatory system; egg chamber; embryonic/larval brain; gastrula embryo; and yolk. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Idgf3 in Genome Data Viewer
    Location:
    36A1-36A1; 2-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16450907..16455194)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16450907..16455194)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 1 Neighboring gene Imaginal disc growth factor 2 Neighboring gene dachshund Neighboring gene Neprilysin-like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila. Espinoza CY, et al. G3 (Bethesda), 2020 Oct 5. PMID 32855169, Free PMC Article
    2. The Imaginal Disc Growth Factors 2 and 3 participate in the Drosophila response to nematode infection. Yadav S, et al. Parasite Immunol, 2018 Oct. PMID 30107045
    3. The Drosophila Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing. Kucerova L, et al. J Innate Immun, 2016. PMID 26694862, Free PMC Article
    4. Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism. Towler BP, et al. PLoS Genet, 2020 Dec. PMID 33370287, Free PMC Article
    5. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. Varela PF, et al. J Biol Chem, 2002 Apr 12. PMID 11821393

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila.
      Title: Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila.
    2. The results indicate that Idgf2 and Idgf3 might be involved in different yet crucial immune functions in the Drosophila anti-nematode immune response. Idgf2 and Idgf3 modulate distinct immune functions in Drosophila larvae in response to Steinernema nematode infection.
      Title: The Imaginal Disc Growth Factors 2 and 3 participate in the Drosophila response to nematode infection.
    3. IDGF3 has multiple roles in innate immunity. It serves as an essential component required for the formation of hemolymph clots that seal wounds, and Idgf3 mutants display an extended developmental delay during wound healing.
      Title: The Drosophila Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing.
    4. determination of polymorphism patterns
      Title: Polymorphism patterns in two tightly linked developmental genes, Idgf1 and Idgf3, of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imaginal disc growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chitin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    imaginal disc growth factor 3
    Names
    CG4559-PA
    CG4559-PB
    CG4559-PC
    CG4559-PD
    Idgf3-PA
    Idgf3-PB
    Idgf3-PC
    Idgf3-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16450907..16455194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165158.1 → NP_723967.1  imaginal disc growth factor 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9
      UniProtKB/TrEMBL
      X2JA18
      Related
      FBpp0080419, FBtr0080862
      Conserved Domains (2) summary
      cd02873
      Location:26 → 440
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 419
      Glyco_18; Glyco_18 domain

    2. NM_001299053.1 → NP_001285982.1  imaginal disc growth factor 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285982.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9
      UniProtKB/TrEMBL
      X2JA18
      Conserved Domains (2) summary
      cd02873
      Location:26 → 440
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 419
      Glyco_18; Glyco_18 domain

    3. NM_165157.2 → NP_723966.1  imaginal disc growth factor 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9
      UniProtKB/TrEMBL
      X2JA18
      Related
      FBpp0080420
      Conserved Domains (2) summary
      cd02873
      Location:26 → 440
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 419
      Glyco_18; Glyco_18 domain

    4. NM_057908.4 → NP_477256.1  imaginal disc growth factor 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9
      UniProtKB/TrEMBL
      X2JA18
      Related
      FBpp0080421
      Conserved Domains (2) summary
      cd02873
      Location:26 → 440
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 419
      Glyco_18; Glyco_18 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLZ7.3 Q8MLZ7
    X2JA18 X2JA18

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