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    Cdc14 Cell division cycle 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34067, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cdc14provided by FlyBase
    Official Full Name
    Cell division cycle 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0031952
    Locus tag
    Dmel_CG7134
    See related
    AllianceGenome:FB:FBgn0031952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CDC-14; cdc14; CDC14; CG7134; Dmel\CG7134
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including cilium assembly; peptidyl-tyrosine dephosphorylation; and regulation of cell cycle process. Predicted to be located in nucleus. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleolus. Is expressed in several structures, including anterior midgut primordium; embryonic/larval midgut; endoderm; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to several human genes including CDC14A (cell division cycle 14A) and CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cdc14 in Genome Data Viewer
    Location:
    28C4-28C4; 2-28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7801668..7810703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7801668..7810703, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lysine ketoglutarate reductase/saccharopine dehydrogenase Neighboring gene long non-coding RNA:CR44825 Neighboring gene Homocysteine-induced endoplasmic reticulum protein Neighboring gene r2d2 Neighboring gene LanB1 Neighboring gene antisense RNA:CR45008 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correction: Characterization of a cdc14 null allele in Drosophila melanogaster (doi:10.1242/bio.035394). Neitzel L, et al. Biol Open, 2018 Aug 22. PMID 30135077, Free PMC Article
    2. Characterization of a cdc14 null allele in Drosophila melanogaster. Neitzel LR, et al. Biol Open, 2018 Jul 9. PMID 29945873, Free PMC Article
    3. Structural basis for protein recognition by B30.2/SPRY domains. Woo JS, et al. Mol Cell, 2006 Dec 28. PMID 17189197
    4. MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes. Wälchli S, et al. Gene, 2000 Aug 8. PMID 10940550
    5. Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. D'Avino PP, et al. J Cell Sci, 2005 Apr 15. PMID 15811947

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinociliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 14
    Names
    CG7134-PA
    CG7134-PB
    CG7134-PC
    CG7134-PD
    CG7134-PE
    Cdc14-PA
    Cdc14-PB
    Cdc14-PC
    Cdc14-PD
    Cdc14-PE
    cdc14
    NP_001162904.1
    NP_001162905.1
    NP_001285721.1
    NP_001285722.1
    NP_609153.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7801668..7810703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298792.1 → NP_001285721.1  cell division cycle 14, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLW7
      Conserved Domains (3) summary
      COG2453
      Location:229 → 330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:19 → 156
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:217 → 331
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001169433.2 → NP_001162904.1  cell division cycle 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0V6
      Conserved Domains (3) summary
      COG2453
      Location:229 → 330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:19 → 156
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:217 → 331
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. NM_001169434.2 → NP_001162905.1  cell division cycle 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHB2
      Conserved Domains (3) summary
      COG2453
      Location:229 → 330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:19 → 156
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:217 → 331
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    4. NM_135309.3 → NP_609153.1  cell division cycle 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLW7
      Related
      FBpp0079115
      Conserved Domains (3) summary
      COG2453
      Location:229 → 330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:19 → 156
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:217 → 331
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    5. NM_001298793.1 → NP_001285722.1  cell division cycle 14, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9T8
      Conserved Domains (3) summary
      COG2453
      Location:229 → 330
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:19 → 156
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:217 → 331
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHB2 E1JHB2
    Q5U0V6 Q5U0V6
    Q9VLW7 Q9VLW7
    X2J9T8 X2J9T8

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