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    cort cortex [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33937, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cortprovided by FlyBase
    Official Full Name
    cortexprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000351
    Locus tag
    Dmel_CG11330
    See related
    AllianceGenome:FB:FBgn0000351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11330; cor; Cort; Dmel\CG11330
    Summary
    Enables anaphase-promoting complex binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; female meiotic nuclear division; and positive regulation of cellular protein metabolic process. Located in cytoplasm. Is expressed in adult heart. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See cort in Genome Data Viewer
    Location:
    26F7-26F7; 2-21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6674682..6676635, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6674682..6676635, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene Galactose-1-phosphate uridylyltransferase Neighboring gene Serpin 27A Neighboring gene Non-SMC element 1 Neighboring gene Na[+]/H[+] hydrogen exchanger 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition. Kronja I, et al. Proc Natl Acad Sci U S A, 2014 Nov 11. PMID 25349405, Free PMC Article
    2. Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Swan A, et al. Cell Cycle, 2005 Oct. PMID 16138012
    3. Cytoplasmic polyadenylation of Toll mRNA is required for dorsal-ventral patterning in Drosophila embryogenesis. Schisa JA, et al. Development, 1998 Aug. PMID 9655821
    4. The only function of Grauzone required for Drosophila oocyte meiosis is transcriptional activation of the cortex gene. Harms E, et al. Genetics, 2000 Aug. PMID 10924478, Free PMC Article
    5. Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein. Chen B, et al. Development, 2000 Mar. PMID 10683177

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate APC(Cort) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence.
      Title: A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.
    2. CORT physically associates with core subunits of the APC/C in ovaries. APC/C(CORT) targets Cyclin A for degradation prior to the metaphase I arrest, while Cyclins B and B3 are not targeted until after egg activation.
      Title: Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator.
    3. Cks30A interacts with Cdk1 to target cyclin A for destruction in the female germline, possibly through the activation of a novel germline specific CDC20 protein, Cortex
      Title: Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction.
    4. Cyclin B associates with spindle microtubules throughout meiosis I and meiosis II, and dissociates from the meiotic spindle in anaphase II. Fzy and Cort are required for this loss of cyclin B from the meiotic spindle.
      Title: The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables anaphase-promoting complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellularization HMP PubMed 
    involved_in egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in female meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome segregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole cell formation HMP PubMed 
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cortex
    Names
    CG11330-PA
    CG11330-PB
    cdc20-like
    cort-PA
    cort-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6674682..6676635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078770.2 → NP_523494.1  cortex, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960N3, Q9VMA1
      UniProtKB/TrEMBL
      M9PCR0
      Related
      FBpp0078949
      Conserved Domains (3) summary
      COG2319
      Location:166 → 453
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:201 → 244
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:166 → 451
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001273215.1 → NP_001260144.1  cortex, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960N3, Q9VMA1
      UniProtKB/TrEMBL
      M9PCR0
      Conserved Domains (3) summary
      COG2319
      Location:166 → 453
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:201 → 244
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:166 → 451
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCR0 M9PCR0
    Q960N3.2 Q960N3

    Gene LinkOut

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