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    Tango1 Transport and Golgi organization 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Tango1provided by FlyBase
    Official Full Name
    Transport and Golgi organization 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0286898
    Locus tag
    Dmel_CG11098
    See related
    AllianceGenome:FB:FBgn0286898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2L3443; CG11098; Dmel\CG11098; tango1; TANGO1
    Summary
    Predicted to enable chaperone binding activity. Involved in several processes, including Golgi organization; protein secretion; and secretory granule organization. Located in Golgi cis cisterna and endoplasmic reticulum exit site. Is expressed in adult head and follicle cell. Orthologous to several human genes including MIA2 (MIA SH3 domain ER export factor 2) and MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Tango1 in Genome Data Viewer
    Location:
    26F3-26F5; 2-21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6649388..6654574)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6649388..6654574)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 26F Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tango1 coordinates the formation of endoplasmic reticulum/Golgi docking sites to mediate secretory granule formation. Reynolds HM, et al. J Biol Chem, 2019 Dec 20. PMID 31690624, Free PMC Article
    2. Tales of the ER-Golgi Frontier: Drosophila-Centric Considerations on Tango1 Function. Feng Z, et al. Front Cell Dev Biol, 2020. PMID 33505971, Free PMC Article
    3. Accumulation of Laminin Monomers in Drosophila Glia Leads to Glial Endoplasmic Reticulum Stress and Disrupted Larval Locomotion. Petley-Ragan LM, et al. J Neurosci, 2016 Jan 27. PMID 26818504, Free PMC Article
    4. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Saito K, et al. Cell, 2009 Mar 6. PMID 19269366
    5. In vivo models of mucin biosynthesis and function. Syed ZA, et al. Adv Drug Deliv Rev, 2022 May. PMID 35278522, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p24-Tango1 interactions ensure ER-Golgi interface stability and efficient transport.
      Title: p24-Tango1 interactions ensure ER-Golgi interface stability and efficient transport.
    2. Tango1 organizes an interaction site where secretory cargo is efficiently transferred from the endoplasmic reticulum to Golgi and then to secretory vesicles
      Title: Tango1 coordinates the formation of endoplasmic reticulum/Golgi docking sites to mediate secretory granule formation.
    3. PGANT4 is an O-glycosyltransferase that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein, Tango1 and conferring protection from furin-mediated proteolysis
      Title: O-glycosylation regulates polarized secretion by modulating Tango1 stability.
    4. identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag targets Rab10 to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface
      Title: A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis.
    5. Study provides evidence that TANGO1 is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and a cytoplasmic proline-rich domain (PRD).
      Title: TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transport and golgi organization 1
    Names
    CG11098-PA
    CG11098-PC
    CG11098-PD
    Tango1-PA
    Tango1-PC
    Tango1-PD
    transport and golgi organisation 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6649388..6654574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135214.4 → NP_609058.2  transport and golgi organization 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609058.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY42, Q9VMA7, Q9VMA8
      Related
      FBpp0078925
      Conserved Domains (5) summary
      pfam06346
      Location:1291 → 1337
      Drf_FH1; Formin Homology Region 1
      pfam12474
      Location:496 → 606
      PKK; Polo kinase kinase
      cd16269
      Location:560 → 571
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:42 → 113
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:495 → 585
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001298755.1 → NP_001285684.1  transport and golgi organization 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J786
      Conserved Domains (5) summary
      COG1196
      Location:495 → 1204
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06346
      Location:1285 → 1331
      Drf_FH1; Formin Homology Region 1
      cd16269
      Location:560 → 571
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:42 → 113
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:495 → 585
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_164697.3 → NP_723198.2  transport and golgi organization 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723198.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY42, Q9VMA7, Q9VMA8
      Conserved Domains (5) summary
      pfam06346
      Location:1291 → 1337
      Drf_FH1; Formin Homology Region 1
      pfam12474
      Location:496 → 606
      PKK; Polo kinase kinase
      cd16269
      Location:560 → 571
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:42 → 113
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:495 → 585
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMA7.2 Q9VMA7
    X2J786 X2J786

    Gene LinkOut

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