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    Mia3 MIA SH3 domain ER export factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 338366, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mia3provided by MGI
    Official Full Name
    MIA SH3 domain ER export factor 3provided by MGI
    Primary source
    MGI:MGI:2443183
    See related
    Ensembl:ENSMUSG00000056050 AllianceGenome:MGI:2443183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tango; Gm1525; TANGO1; 9130229H14Rik; A930039G15Rik; B230399H06Rik
    Summary
    Predicted to enable cargo receptor activity. Acts upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Located in endoplasmic reticulum membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart; nervous system; and nose. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 13.7), colon adult (RPKM 13.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mia3 in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183107091..183151091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183326236..183369565, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene axin interactor, dorsalization associated Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, A Neighboring gene hedgehog interacting protein-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration. Lei Y, et al. Front Endocrinol (Lausanne), 2021. PMID 34858331, Free PMC Article
    2. Characterization and expression pattern of the novel MIA homolog TANGO. Bosserhoff AK, et al. Gene Expr Patterns, 2004 Jul. PMID 15183315
    3. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
    4. Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. Moser M, et al. Mol Cell Biol, 2002 Mar. PMID 11839810, Free PMC Article
    5. Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. Wilson DG, et al. J Cell Biol, 2011 May 30. PMID 21606205, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.
      Title: MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.
    2. Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms
      Title: Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.
    3. revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family
      Title: Characterization and expression pattern of the novel MIA homolog TANGO.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization protein 1 homolog
    Names
    melanoma inhibitory activity 3
    melanoma inhibitory activity protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177389.4 → NP_796363.3  transport and Golgi organization protein 1 homolog precursor

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108037, AEKQ02108038, CAAA01083531
      UniProtKB/Swiss-Prot
      A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
      UniProtKB/TrEMBL
      A0A0R4J2D3
      Related
      ENSMUSP00000141268.4, ENSMUST00000194543.4
      Conserved Domains (4) summary
      PHA03247
      Location:1014 → 1144
      PHA03247; large tegument protein UL36; Provisional
      PRK14949
      Location:716 → 1119
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      TIGR02168
      Location:1241 → 1606
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17036
      Location:38 → 109
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      183107091..183151091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165968.1 → XP_036021861.1  transport and Golgi organization protein 1 homolog isoform X3

      UniProtKB/Swiss-Prot
      A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
      Conserved Domains (4) summary
      PHA03247
      Location:1014 → 1144
      PHA03247; large tegument protein UL36; Provisional
      PRK14949
      Location:716 → 1119
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      TIGR02168
      Location:1241 → 1606
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17036
      Location:38 → 109
      SH3; Src Homology 3 domain superfamily

    2. XM_036165967.1 → XP_036021860.1  transport and Golgi organization protein 1 homolog isoform X2

      UniProtKB/Swiss-Prot
      A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
      Conserved Domains (4) summary
      PHA03247
      Location:1014 → 1144
      PHA03247; large tegument protein UL36; Provisional
      PRK14949
      Location:716 → 1119
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      TIGR02168
      Location:1241 → 1606
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17036
      Location:38 → 109
      SH3; Src Homology 3 domain superfamily

    3. XM_036165966.1 → XP_036021859.1  transport and Golgi organization protein 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
      Conserved Domains (4) summary
      PHA03247
      Location:1671 → 1954
      PHA03247; large tegument protein UL36; Provisional
      PRK14949
      Location:716 → 1119
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      TIGR04523
      Location:1239 → 1625
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cl17036
      Location:38 → 109
      SH3; Src Homology 3 domain superfamily

    4. XM_036165972.1 → XP_036021865.1  transport and Golgi organization protein 1 homolog isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:514 → 805
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:92 → 457
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06409
      Location:43 → 82
      NPIP; Nuclear pore complex interacting protein (NPIP)

    5. XM_036165973.1 → XP_036021866.1  transport and Golgi organization protein 1 homolog isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:522 → 781
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:92 → 457
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06409
      Location:43 → 82
      NPIP; Nuclear pore complex interacting protein (NPIP)

    RNA

    1. XR_004942926.1 RNA Sequence

    2. XR_004942925.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI84.2 GenPept UniProtKB/Swiss-Prot:Q8BI84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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