chic chickadee [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chicprovided by FlyBase
Official Full Name: chickadeeprovided by FlyBase
Primary source: FLYBASE:FBgn0000308
Locus tag: Dmel_CG9553
See related: AllianceGenome:FB:FBgn0000308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9553; chi; Chi; Chic; ChicE1; D88; Dmel\CG9553; GH4; l(2)27/7; prof; profilin; sand
Summary: Predicted to enable actin monomer binding activity. Involved in several processes, including nervous system development; positive regulation of cell projection organization; and post-embryonic animal morphogenesis. Located in neuron projection and perinuclear region of cytoplasm. Is expressed in adult heart; larval ventral nerve cord; and ovary. Used to study cardiomyopathy and myopathy. Orthologous to human PFN4 (profilin family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 26A5-26B2; 2-18 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5972115..5981018, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5972115..5981018, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.
Title: Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.
Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
Title: Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
Title: Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
Title: Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
Insulin/Insulin-like growth factor signaling specifically activates the expression of the actin regulator chickadee, the Drosophila homolog of Profilin, which is essential for promoting the formation of actin extensions and migration through the egg chamber.and migration through the egg chamber.
Title: The Drosophila insulin pathway controls Profilin expression and dynamic actin-rich protrusions during collective cell migration.
Chic regulates interactions across the somatic permeability barrier around the germline that is essential for Drosophila spermatogenesis.
Title: A somatic permeability barrier around the germline is essential for Drosophila spermatogenesis.
chickadee, the Drosophila gene that encodes profilin, is required cell autonomously to maintain germline stem cells, possibly facilitating localization or maintenance of E-cadherin to the germline stem cell-hub cell interface.
Title: The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.
Data show that chic-deficient larvae fail to form a robust actin cable along the wound edge and also fail to form normal filopodial and lamellipodial extensions into the wound gap.
Title: Transcriptional regulation of Profilin during wound closure in Drosophila larvae.
D. melanogaster DAAM formin represents an extreme class of barbed end regulators gated by profilin.
Title: Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM.
FMRP1 binds the mRNA of the Drosophila profilin and negatively regulates Profilin protein expression
Title: The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0207 (e-PCR)
- UniSTS:30531

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament polymerization	TAS Traceable Author Statement more info	PubMed
involved_in actomyosin contractile ring assembly	TAS Traceable Author Statement more info	PubMed
involved_in brain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in histoblast morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval central nervous system remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in larval salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	HMP more info	PubMed
involved_in pole plasm oskar mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chickadee

Names: CG9553-PA; CG9553-PB; CG9553-PC; CG9553-PD; CG9553-PE; CG9553-PF; DProfilin; chic-PA; chic-PB; chic-PC; chic-PD; chic-PE; chic-PF; chicadee; chickaddee; profilin; stranded