U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FCGRT Fc gamma receptor and transporter [ Bos taurus (domestic cattle) ]

    Gene ID: 338062, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FCGRTprovided by VGNC
    Official Full Name
    Fc gamma receptor and transporterprovided by VGNC
    Primary source
    VGNC:VGNC:28934
    See related
    BGD:BT11421; Ensembl:ENSBTAG00000013926
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FCGRT in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (55961575..55968122)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD35 Neighboring gene ribosomal protein S11 Neighboring gene microRNA mir-150 Neighboring gene reticulocalbin 3 Neighboring gene uncharacterized LOC132342713 Neighboring gene nitric oxide synthase interacting protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice. Szikora B, et al. Front Immunol, 2020. PMID 32973781, Free PMC Article
    2. Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice. Cui D, et al. PLoS One, 2014. PMID 25546424, Free PMC Article
    3. Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum. Zhang R, et al. Anim Biotechnol, 2009. PMID 19937499
    4. Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo. Sayed-Ahmed A, et al. Acta Histochem, 2010 Jul. PMID 19481783
    5. Isolation of the gene encoding the bovine neonatal Fc receptor. Doleschall M, et al. Vet Immunol Immunopathol, 2005 Oct 18. PMID 16095719

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice.
      Title: FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice.
    2. The transport of IgGs in the mammary gland, by FcRn, was investigated.
      Title: Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice.
    3. The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.
      Title: Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo.
    4. haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.
      Title: Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum.
    5. FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified
      Title: Isolation of the gene encoding the bovine neonatal Fc receptor.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-2-microglobulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    IgG receptor FcRn large subunit p51
    Names
    Fc fragment of IgG receptor and transporter
    Fc fragment of IgG, receptor, transporter, alpha
    Fc receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176657.1 → NP_788830.1  IgG receptor FcRn large subunit p51 precursor

      See identical proteins and their annotated locations for NP_788830.1

      Status: PROVISIONAL

      Source sequence(s)
      AF139106
      UniProtKB/TrEMBL
      A0AAA9RWF7, Q3T119
      Related
      ENSBTAP00000031824.3, ENSBTAT00000031878.3
      Conserved Domains (2) summary
      cl08246
      Location:29 → 196
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:200 → 290
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      55961575..55968122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977965.1 → XP_024833733.1  IgG receptor FcRn large subunit p51 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RWF7, F6R592
      Related
      ENSBTAP00000018500.3, ENSBTAT00000018500.4
      Conserved Domains (2) summary
      cl08246
      Location:40 → 207
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:211 → 301
      Ig; Immunoglobulin domain

    2. XM_005219176.5 → XP_005219233.1  IgG receptor FcRn large subunit p51 isoform X2

      See identical proteins and their annotated locations for XP_005219233.1

      UniProtKB/TrEMBL
      A0AAA9RWF7, Q3T119
      Related
      ENSBTAP00000040745.1, ENSBTAT00000043155.2
      Conserved Domains (2) summary
      cl08246
      Location:29 → 196
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:200 → 290
      Ig; Immunoglobulin domain

    3. XM_005219175.5 → XP_005219232.1  IgG receptor FcRn large subunit p51 isoform X2

      See identical proteins and their annotated locations for XP_005219232.1

      UniProtKB/TrEMBL
      A0AAA9RWF7, Q3T119
      Conserved Domains (2) summary
      cl08246
      Location:29 → 196
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:200 → 290
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials