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    MYLK myosin light chain kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 338037, updated on 10-Oct-2024

    Summary

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    Gene symbol
    MYLK
    Gene description
    myosin light chain kinase
    See related
    BGD:BT26108; Ensembl:ENSBTAG00000014567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MLCK; smMLCK
    Orthologs
    human mouse all
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    Genomic context

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    See MYLK in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (67980544..68260061, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene histone H4-like Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene coiled-coil domain containing 14 Neighboring gene U4 spliceosomal RNA Neighboring gene rhophilin associated tail protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histamine-induced myosin light chain phosphorylation breaks down the barrier integrity of cultured corneal epithelial cells. Guo Y, et al. Pharm Res, 2007 Oct. PMID 17479229
    2. Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity. Kobayashi H, et al. J Biochem, 1992 Dec. PMID 1284247
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.
      Title: Histamine-induced myosin light chain phosphorylation breaks down the barrier integrity of cultured corneal epithelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables myosin light chain kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tonic smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    myosin, light polypeptide kinase
    telokin
    NP_001359183.1
    NP_788809.1
    XP_024850108.1
    XP_024850288.1
    XP_024850337.1
    XP_059744877.1
    XP_059744900.1
    XP_059744905.1
    XP_059744920.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372254.1 → NP_001359183.1  myosin light chain kinase, smooth muscle isoform 2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000001
      UniProtKB/TrEMBL
      A0AAA9SPU5
      Related
      ENSBTAP00000019385.7, ENSBTAT00000019385.7
      Conserved Domains (7) summary
      PTZ00449
      Location:869 → 1281
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00063
      Location:1400 → 1491
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14191
      Location:1531 → 1789
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      cd00096
      Location:293 → 358
      Ig; Immunoglobulin domain
      pfam07679
      Location:1879 → 1969
      I-set; Immunoglobulin I-set domain
      pfam16620
      Location:251 → 293
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:1307 → 1404
      Ig; Immunoglobulin domain

    2. NM_176636.3 → NP_788809.1  myosin light chain kinase, smooth muscle isoform 1

      See identical proteins and their annotated locations for NP_788809.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000001
      UniProtKB/Swiss-Prot
      Q28824
      Conserved Domains (5) summary
      PTZ00449
      Location:60 → 361
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00063
      Location:591 → 682
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14191
      Location:722 → 980
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam07679
      Location:1069 → 1159
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:498 → 595
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      67980544..68260061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059888917.1 → XP_059744900.1  myosin light chain kinase, smooth muscle isoform X1

      Related
      ENSBTAP00000084948.1, ENSBTAT00000090379.1

    2. XM_059888922.1 → XP_059744905.1  myosin light chain kinase, smooth muscle isoform X2

      Related
      ENSBTAP00000086784.1, ENSBTAT00000092412.1

    3. XM_059888894.1 → XP_059744877.1  myosin light chain kinase, smooth muscle isoform X1

    4. XM_024994340.2 → XP_024850108.1  myosin light chain kinase, smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0AAA9SPU5
      Related
      ENSBTAP00000088779.1, ENSBTAT00000104917.1
      Conserved Domains (6) summary
      cd00063
      Location:1543 → 1634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:2022 → 2112
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1674 → 1932
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251 → 411
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:1450 → 1547
      Ig; Immunoglobulin domain
      cl25751
      Location:1012 → 1424
      DUF4045; Domain of unknown function (DUF4045)

    5. XM_024994520.2 → XP_024850288.1  myosin light chain kinase, smooth muscle isoform X3

      Conserved Domains (4) summary
      cd05762
      Location:38 → 135
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:131 → 222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:610 → 700
      I-set; Immunoglobulin I-set domain
      cl21453
      Location:262 → 520
      PKc_like; Protein Kinases, catalytic domain

    6. XM_059888937.1 → XP_059744920.1  myosin light chain kinase, smooth muscle isoform X4

    7. XM_024994569.2 → XP_024850337.1  myosin light chain kinase, smooth muscle isoform X5

      Conserved Domains (1) summary
      cd20973
      Location:52 → 139
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28824.1 GenPept UniProtKB/Swiss-Prot:Q28824

    Gene LinkOut

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