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    vri vrille [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33759, updated on 18-Sep-2024

    Summary

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    Official Symbol
    vriprovided by FlyBase
    Official Full Name
    vrilleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016076
    Locus tag
    Dmel_CG14029
    See related
    AllianceGenome:FB:FBgn0016076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    argo; CG14029; DM16; Dmel\CG14029; jf23; l(2)25Db; l(2)jf23; mat(2)ea-G; mat(2)earlyRS32; mel_vri; Vri; VRI; Vrille
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including animal organ morphogenesis; multicellular organism aging; and positive regulation of heart contraction. Located in nucleus. Is expressed in several structures, including digestive system; dorsal closure embryo; epithelium; head; and pacemaker neurons. Orthologous to human NFIL3 (nuclear factor, interleukin 3 regulated). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See vri in Genome Data Viewer
    Location:
    25D4-25D5; 2-16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5288944..5311223)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5288944..5311223)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bub1 kinase Neighboring gene long non-coding RNA:CR44743 Neighboring gene long non-coding RNA:CR44742 Neighboring gene long non-coding RNA:CR45730 Neighboring gene uncharacterized protein Neighboring gene Nuclear receptor coactivator 6 Neighboring gene long non-coding RNA:CR44985

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VRILLE shows high divergence among Higher Diptera flies but may retain role as transcriptional repressor of clock. Rego NFC, et al. J Insect Physiol, 2021 Aug-Sep. PMID 34256034
    2. Circadian disruption of memory consolidation in Drosophila. Yin JCP, et al. Front Syst Neurosci, 2023. PMID 37034015, Free PMC Article
    3. vrille is required to ensure tracheal integrity in Drosophila embryo. Szuplewski S, et al. Dev Growth Differ, 2010 Jun. PMID 20507356
    4. Analysis of the Drosophila Clock promoter reveals heterogeneity in expression between subgroups of central oscillator cells and identifies a novel enhancer region. Gummadova JO, et al. J Biol Rhythms, 2009 Oct. PMID 19755581
    5. Targeted inhibition of Pdp1epsilon abolishes the circadian behavior of Drosophila melanogaster. Lim C, et al. Biochem Biophys Res Commun, 2007 Dec 14. PMID 17950247

    See all (250) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we demonstrate that Vri, the ortholog of the vertebrate NFIL3/E4B4 transcription factor, is a major genetic regulator of cardiac aging. Vri overexpression leads to major heart dysfunctions
      Title: dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila.
    2. E23 forms its own feedback loop in the ecdysone response to control circadian oscillation through ecdysone-mediated vrille expression.
      Title: Membrane-bound transporter controls the circadian transcription of clock genes in Drosophila.
    3. Vrille mutants interfered with tracheal development, but did not produce defects in gut morphology.
      Title: vrille is required to ensure tracheal integrity in Drosophila embryo.
    4. Results show that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone.
      Title: Genomic mapping of binding regions for the Ecdysone receptor protein complex.
    5. Clk, vri, and Pdp-1 have roles in controlling Drosophila circadian oscillations, as shown in a simulation
      Title: Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK.
    6. role for VRI in the rhythmic repression of output genes that cycle in phase with Clk
      Title: VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator.
    7. Results suggest that vrille is required for normal cell growth and proliferation via the regulation of the actin cytoskeleton.
      Title: The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhythmic behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vrille
    Names
    CG14029-PA
    CG14029-PC
    CG14029-PD
    CG14029-PE
    CG14029-PF
    lethal(2)25Db
    maternal effect early arrest G
    vri-PA
    vri-PC
    vri-PD
    vri-PE
    vri-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5288944..5311223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298694.1 → NP_001285623.1  vrille, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTN9, Q8MZ04
      Conserved Domains (1) summary
      cd14694
      Location:119 → 178
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain

    2. NM_164639.2 → NP_723075.1  vrille, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTN9, Q8MZ04
      Related
      FBpp0078705
      Conserved Domains (1) summary
      cd14694
      Location:119 → 178
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain

    3. NM_001298695.1 → NP_001285624.1  vrille, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18660, Q9VMS4
      Conserved Domains (1) summary
      cd14694
      Location:238 → 297
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain

    4. NM_057843.4 → NP_477191.1  vrille, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18660, Q9VMS4
      Related
      FBpp0078706
      Conserved Domains (1) summary
      cd14694
      Location:238 → 297
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain

    5. NM_001144320.2 → NP_001137792.1  vrille, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18660, Q9VMS4
      Conserved Domains (1) summary
      cd14694
      Location:238 → 297
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18660 O18660
    Q7KTN9 Q7KTN9
    Q8MZ04 Q8MZ04
    Q9VMS4 Q9VMS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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