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    Atet ABC transporter expressed in trachea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33636, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Atetprovided by FlyBase
    Official Full Name
    ABC transporter expressed in tracheaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020762
    Locus tag
    Dmel_CG2969
    See related
    AllianceGenome:FB:FBgn0020762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATET; CG2969; DmAter; Dmel\CG2969
    Summary
    Enables ATPase-coupled transmembrane transporter activity. Involved in transmembrane transport. Located in exocytic vesicle membrane. Is integral component of plasma membrane. Is expressed in several structures, including dorsal ectoderm; ectoderm anlage; embryonic/larval circulatory system; epidermis; and extended germ band embryo. Orthologous to several human genes including ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Atet in Genome Data Viewer
    Location:
    24E1-24E1; 2-12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4333913..4345776)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4333913..4345776)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene turtle Neighboring gene borderless Neighboring gene long non-coding RNA:CR44697 Neighboring gene long non-coding RNA:CR44698 Neighboring gene mir-1005 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the ABC transporter expressed in Trachea (ATET) gene from Drosophila melanogaster. Kuwana H, et al. Biochim Biophys Acta, 1996 Nov 11. PMID 8950175
    2. Transporter-mediated ecdysteroid trafficking across cell membranes: A novel target for insect growth regulators. Okamoto N, et al. J Pestic Sci, 2021 Feb 20. PMID 33746543, Free PMC Article
    3. Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis. Myers JL, et al. Int J Mol Sci, 2021 Nov 30. PMID 34884779, Free PMC Article
    4. Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing. Shimell M, et al. Development, 2018 Mar 14. PMID 29467242, Free PMC Article
    5. Egfr Signaling Is a Major Regulator of Ecdysone Biosynthesis in the Drosophila Prothoracic Gland. Cruz J, et al. Curr Biol, 2020 Apr 20. PMID 32220314

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in exocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABC transporter expressed in trachea
    Names
    Atet-PA
    Atet-PB
    Atet-PC
    Atet-PD
    CG2969-PA
    CG2969-PB
    CG2969-PC
    CG2969-PD
    NP_001097078.1
    NP_001097079.1
    NP_523471.2
    NP_722971.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4333913..4345776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103609.3 → NP_001097079.1  ABC transporter expressed in trachea, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS50, Q9VQY4
      Conserved Domains (3) summary
      cd03213
      Location:142 → 366
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:137 → 825
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:564 → 767
      ABC2_membrane; ABC-2 type transporter

    2. NM_078747.3 → NP_523471.2  ABC transporter expressed in trachea, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523471.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS50, Q9VQY4
      Related
      FBpp0077116
      Conserved Domains (3) summary
      cd03213
      Location:142 → 366
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:137 → 825
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:564 → 767
      ABC2_membrane; ABC-2 type transporter

    3. NM_164580.2 → NP_722971.1  ABC transporter expressed in trachea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS50, Q9VQY4
      Related
      FBpp0077117
      Conserved Domains (3) summary
      cd03213
      Location:142 → 366
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:137 → 825
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:564 → 767
      ABC2_membrane; ABC-2 type transporter

    4. NM_001103608.2 → NP_001097078.1  ABC transporter expressed in trachea, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVF0, Q8MS50
      Conserved Domains (3) summary
      cd03213
      Location:128 → 352
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:123 → 811
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:550 → 753
      ABC2_membrane; ABC-2 type transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RVF0 A2RVF0
    Q8MS50 Q8MS50
    Q9UAF0 Q9UAF0
    Q9VQY4 Q9VQY4

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