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    Hydr2 alpha/beta hydrolase2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33532, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hydr2provided by FlyBase
    Official Full Name
    alpha/beta hydrolase2provided by FlyBase
    Primary source
    FLYBASE:FBgn0014906
    Locus tag
    Dmel_CG3488
    See related
    AllianceGenome:FB:FBgn0014906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-23D; anon-23Da; c24; C24; cg3488; CG3488; CT11757; Dmel\CG3488; DMU29170; HYDR2
    Summary
    Enables lipase activity. Involved in lipid metabolic process. Predicted to be active in sperm flagellum and sperm plasma membrane. Is expressed in adult head and organism. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Hydr2 in Genome Data Viewer
    Location:
    23D4-23D4; 2-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3163645..3169462)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3163645..3169462)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene glaikit Neighboring gene pseudo Neighboring gene transfer RNA:Serine-AGA 2-3 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel gene glaikit, is expressed during neurogenesis in the Drosophila melanogaster embryo. Dunlop J, et al. Mech Dev, 2000 Aug. PMID 10940635
    2. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Sekelsky JJ, et al. Genetics, 1995 Mar. PMID 7768443, Free PMC Article
    3. Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Wiersdorff V, et al. Development, 1996 Jul. PMID 8681796
    4. Regulation of sumo mRNA during endoplasmic reticulum stress. Moore KA, et al. PLoS One, 2013. PMID 24058701, Free PMC Article
    5. Alpha/beta hydrolase2, a predicated gene adjacent to mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity. Wisotzkey RG, et al. J Mol Evol, 2003 Mar. PMID 12612838

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in medium-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid hormone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta hydrolase2
    Names
    CG3488-PA
    CG3488-PB
    CG3488-PC
    Hydr2-PA
    Hydr2-PB
    Hydr2-PC
    NP_001245852.1
    NP_001259993.1
    NP_608751.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3163645..3169462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258923.2 → NP_001245852.1  alpha/beta hydrolase2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24093, Q9VQM6
      UniProtKB/TrEMBL
      M9NDD5
      Conserved Domains (2) summary
      pfam00561
      Location:115 → 365
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:51 → 381
      Abhydrolase; alpha/beta hydrolases

    2. NM_001273064.1 → NP_001259993.1  alpha/beta hydrolase2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEM9
      Conserved Domains (2) summary
      pfam00561
      Location:28 → 278
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:5 → 294
      Abhydrolase; alpha/beta hydrolases

    3. NM_134907.4 → NP_608751.2  alpha/beta hydrolase2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608751.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24093, Q9VQM6
      UniProtKB/TrEMBL
      M9NDD5
      Related
      FBpp0077265
      Conserved Domains (2) summary
      pfam00561
      Location:115 → 365
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:51 → 381
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5AEM9 D5AEM9
    M9NDD5 M9NDD5
    Q24093.2 Q24093

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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