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    Iris iris [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33290, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Irisprovided by FlyBase
    Official Full Name
    irisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031305
    Locus tag
    Dmel_CG4715
    See related
    AllianceGenome:FB:FBgn0031305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4715; CG4715-env; Dm-cF; Dmel\CG4715
    Summary
    Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Iris in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1132332..1134098, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1132332..1134098, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pinocchio Neighboring gene TBC1 domain family member 23 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cellular Drosophila melanogaster protein with similarity to baculovirus F envelope fusion proteins. Lung O, et al. J Virol, 2005 Jul. PMID 15956544, Free PMC Article
    2. [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome]. Makhnovskii PA, et al. Mol Biol (Mosk), 2016 May-Jun. PMID 27414781
    3. Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster. Malik HS, et al. PLoS Genet, 2005 Oct. PMID 16244705, Free PMC Article
    4. Allelic imbalance in Drosophila hybrid heads: exons, isoforms, and evolution. Graze RM, et al. Mol Biol Evol, 2012 Jun. PMID 22319150, Free PMC Article
    5. Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis. Zhu L, et al. RNA Biol, 2019 Oct. PMID 31195914, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iris is not involved in immune responses, but it apparently performs a cell function that is inhibited in stress.
      Title: [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome].
    2. Iris has "switched sides," having been recruited by host genomes to combat baculoviruses and retroviruses, which employ homologous envelope genes to mediate infection
      Title: Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    iris
    Names
    CG4715-PA
    Iris-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1132332..1134098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134726.3 → NP_608570.1  iris [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q30CQ7, Q30CR0, Q9VPX0
      Related
      FBpp0077651
      Conserved Domains (2) summary
      pfam12259
      Location:176 → 530
      DUF3609; Protein of unknown function (DUF3609)
      pfam12272
      Location:1 → 155
      DUF3610; Protein of unknown function (DUF3610)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPX0 Q9VPX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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