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    Gs1 Glutamine synthetase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33172, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Gs1provided by FlyBase
    Official Full Name
    Glutamine synthetase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0001142
    Locus tag
    Dmel_CG2718
    See related
    AllianceGenome:FB:FBgn0001142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2718; Dmel\CG2718; fs(2)P52; fs(2)throng; gs-m; GS1; gsI; GsI; GSI; l(2)21Bc; mt-gs; thg
    Summary
    Enables glutamate-ammonia ligase activity. Involved in L-glutamine biosynthetic process; phagocytosis; and positive regulation of mitochondrial fusion. Located in mitochondrion. Is expressed in several structures, including apoptotic amnioserosa; circulatory system; embryonic epidermis; embryonic/larval muscle system; and extended germ band embryo. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Gs1 in Genome Data Viewer
    Location:
    21B2-21B3; 2-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (132077..134472)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (132077..134472)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44969 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44185 Neighboring gene long non-coding RNA:CR44186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a copy of Tirant transposable element in Drosophila melanogaster. Viggiano L, et al. Gene, 1997 Sep 15. PMID 9332347
    2. The enzyme glutamine synthetase I of Drosophila melanogaster is associated with a modified RNA. Caizzi R, et al. Biochem Genet, 1983 Apr. PMID 6190476
    3. Purification of the glutamine synthetase II isozyme of Drosophila melanogaster and structural and functional comparison of glutamine synthetases I and II. De Pinto V, et al. Biochem Genet, 1987 Dec. PMID 2897195
    4. Homologous nuclear genes encode cytoplasmic and mitochondrial glutamine synthetase in Drosophila melanogaster. Caizzi R, et al. J Mol Biol, 1990 Mar 5. PMID 1969491
    5. Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster. Lyu Y, et al. Commun Biol, 2021 Jun 15. PMID 34131274, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington's Disease.
      Title: Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington's Disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamine synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in L-glutamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamine synthetase 1
    Names
    CG2718-PB
    CG2718-PC
    CG2718-PD
    Glutamate-ammonia ligase
    Gs1-PB
    Gs1-PC
    Gs1-PD
    glutamine synthase 1
    glutamine synthetase
    glutamine synthetase I
    glutamine synthetase-1
    mitochondrial glutamine synthetase
    throng
    NP_001162839.1
    NP_476570.1
    NP_722606.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      132077..134472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164367.2 → NP_722606.1  glutamine synthetase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722606.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX3, O96770, P20477, Q9VPK0
      UniProtKB/TrEMBL
      E1JHQ1
      Related
      FBpp0077774
      Conserved Domains (2) summary
      PLN02284
      Location:54 → 398
      PLN02284; glutamine synthetase
      pfam00120
      Location:151 → 385
      Gln-synt_C; Glutamine synthetase, catalytic domain

    2. NM_057222.4 → NP_476570.1  glutamine synthetase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX3, O96770, P20477, Q9VPK0
      UniProtKB/TrEMBL
      E1JHQ1
      Related
      FBpp0077773
      Conserved Domains (2) summary
      PLN02284
      Location:54 → 398
      PLN02284; glutamine synthetase
      pfam00120
      Location:151 → 385
      Gln-synt_C; Glutamine synthetase, catalytic domain

    3. NM_001169368.3 → NP_001162839.1  glutamine synthetase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX3, O96770, P20477, Q9VPK0
      UniProtKB/TrEMBL
      E1JHQ1
      Conserved Domains (2) summary
      PLN02284
      Location:54 → 398
      PLN02284; glutamine synthetase
      pfam00120
      Location:151 → 385
      Gln-synt_C; Glutamine synthetase, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHQ1 E1JHQ1
    P20477.3 P20477

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