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    dod dodo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33111, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dodprovided by FlyBase
    Official Full Name
    dodoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015379
    Locus tag
    Dmel_CG17051
    See related
    AllianceGenome:FB:FBgn0015379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17051; Dmel\CG17051; Pin1
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Involved in positive regulation of protein ubiquitination and regulation of locomotor rhythm. Located in nucleus. Is expressed in adult heart. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See dod in Genome Data Viewer
    Location:
    19F5-19F5; 1-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21345358..21346858)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21216385..21217885)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene tweety Neighboring gene flightless I Neighboring gene penguin Neighboring gene small optic lobes Neighboring gene Septin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pinning down cell division? Miklos GL, et al. Science, 1998 Feb 27. PMID 9508696
    2. The dodo gene family encodes a novel protein involved in signal transduction and protein folding. Maleszka R, et al. Gene, 1997 Dec 12. PMID 9426238
    3. Drosophila peptidyl-prolyl isomerase Pin1 modulates circadian rhythms via regulating levels of PERIOD. Kang SW, et al. Biochem Biophys Res Commun, 2015 Jul 31. PMID 25998391
    4. The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. Campbell HD, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248259, Free PMC Article
    5. Pin-pointing MAPK signalling. Freeman M. Nat Cell Biol, 2001 Jun. PMID 11389451

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
      Title: The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
    2. Overexpression of Drosophila pin1, dod, lengthens the circadian period.
      Title: Drosophila peptidyl-prolyl isomerase Pin1 modulates circadian rhythms via regulating levels of PERIOD.
    3. The function of the Dodo protein is to facilitate the degradation of transcription factor CF2 which also requires activated epidermal growth factor receptor-MAPK signalling.
      Title: Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dodo
    Names
    CG17051-PA
    dod-PA
    drosophila pin1
    NP_523428.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21345358..21346858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078704.4 → NP_523428.1  dodo [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP71, O61344, P54353, Q9VRH1
      Related
      FBpp0076894
      Conserved Domains (2) summary
      PTZ00356
      Location:55 → 166
      PTZ00356; peptidyl-prolyl cis-trans isomerase (PPIase); Provisional
      smart00456
      Location:7 → 39
      WW; Domain with 2 conserved Trp (W) residues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54353.3 P54353

    Gene LinkOut

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