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    Ser6 Serine protease 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33073, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Ser6provided by FlyBase
    Official Full Name
    Serine protease 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0011834
    Locus tag
    Dmel_CG2071
    See related
    AllianceGenome:FB:FBgn0011834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2071; Dmel\CG2071; SP47
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Ser6 in Genome Data Viewer
    Location:
    19E5-19E5; 1-65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20962605..20963505, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20833632..20834532, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Niemann-Pick type C-1b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of Drosophila melanogaster laboratory strains of different geographical origin after long-term laboratory maintenance. Zarubin M, et al. Ecol Evol, 2020 Jul. PMID 32760513, Free PMC Article
    2. Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure. Rollmann SM, et al. Genetics, 2008 Jul. PMID 18562639, Free PMC Article
    3. Genome-wide analysis of genes associated with moderate and high DDT resistance in Drosophila melanogaster. Qiu X, et al. Pest Manag Sci, 2013 Aug. PMID 23371854
    4. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
    5. Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning. Iyer EP, et al. PLoS One, 2013. PMID 23977298, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease 6
    Names
    CG2071-PA
    Ser6-PA
    NP_523426.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20962605..20963505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078702.2 → NP_523426.1  serine protease 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRD0
      Related
      FBpp0076964
      Conserved Domains (2) summary
      smart00020
      Location:31 → 253
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:32 → 256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23987 Q23987
    Q9VRD0 Q9VRD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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