U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Pfrx 6-phosphofructo-2-kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32938, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pfrxprovided by FlyBase
    Official Full Name
    6-phosphofructo-2-kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027621
    Locus tag
    Dmel_CG3400
    See related
    AllianceGenome:FB:FBgn0027621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3400; Dmel\CG3400; pfk2; Pfk2; PFK2
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; and glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including ectoderm anlage; extended germ band embryo; germ layer; stage 5 embryo; and wing disc. Orthologous to several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pfrx in Genome Data Viewer
    Location:
    18C8-18C8; 1-62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19495505..19509350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19389538..19403383)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 18 kDa subunit Neighboring gene uncharacterized protein Neighboring gene kish Neighboring gene Isocitrate dehydrogenase 3a Neighboring gene CoRest

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment. Jones MA, et al. Exp Gerontol, 2009 Aug. PMID 19481596, Free PMC Article
    2. Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. Havula E, et al. PLoS Genet, 2013 Apr. PMID 23593032, Free PMC Article
    3. Hyperpolarized mitochondria accumulate in Drosophila Hipk-overexpressing cells to drive tumor-like growth. Wong KKL, et al. J Cell Sci, 2020 Dec 9. PMID 33199523, Free PMC Article
    4. Age-Related Increase in Lactate Dehydrogenase Activity in Skeletal Muscle Reduces Life Span in Drosophila. Hunt LC, et al. J Gerontol A Biol Sci Med Sci, 2022 Feb 3. PMID 34477202, Free PMC Article
    5. Adenylate kinase 2 deficiency limits survival and regulates various genes during larval stages of Drosophila melanogaster. Horiguchi T, et al. J Med Invest, 2014. PMID 24705759

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 19502475-19502972 mobile_element_type = transposon:FB{}5617

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphofructo-2-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of glycolytic process through fructose-6-phosphate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    6-phosphofructo-2-kinase
    Names
    CG3400-PA
    CG3400-PB
    CG3400-PD
    CG3400-PE
    CG3400-PF
    CG3400-PG
    CG3400-PH
    CG3400-PI
    CG3400-PJ
    CG3400-PK
    CG3400-PL
    CG3400-PM
    CG3400-PN
    Pfrx-PA
    Pfrx-PB
    Pfrx-PD
    Pfrx-PE
    Pfrx-PF
    Pfrx-PG
    Pfrx-PH
    Pfrx-PI
    Pfrx-PJ
    Pfrx-PK
    Pfrx-PL
    Pfrx-PM
    Pfrx-PN
    fi-phosphofructo-2-kinase
    fructose 2,6 bisphosphatase
    phosphofructokinase
    NP_001245750.1
    NP_001245751.1
    NP_001245752.1
    NP_001285440.1
    NP_001285441.1
    NP_477451.1
    NP_477452.3
    NP_728249.1
    NP_728250.1
    NP_728251.1
    NP_728252.1
    NP_728253.1
    NP_728254.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19495505..19509350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167654.2 → NP_728252.1  6-phosphofructo-2-kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074482
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    2. NM_001258821.2 → NP_001245750.1  6-phosphofructo-2-kinase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    3. NM_167651.2 → NP_728249.1  6-phosphofructo-2-kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728249.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074483
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    4. NM_167656.2 → NP_728254.1  6-phosphofructo-2-kinase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074484
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    5. NM_058104.5 → NP_477452.3  6-phosphofructo-2-kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477452.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWH7, Q9Y1W2
      Related
      FBpp0074486
      Conserved Domains (3) summary
      pfam00300
      Location:468 → 651
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:254 → 465
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:256 → 412
      AAA_33; AAA domain

    6. NM_001298512.1 → NP_001285441.1  6-phosphofructo-2-kinase, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JED9
      Conserved Domains (3) summary
      pfam00300
      Location:467 → 650
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:253 → 464
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:255 → 411
      AAA_33; AAA domain

    7. NM_058103.3 → NP_477451.1  6-phosphofructo-2-kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWH7, Q9Y1W2
      Related
      FBpp0074485
      Conserved Domains (3) summary
      pfam00300
      Location:468 → 651
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:254 → 465
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:256 → 412
      AAA_33; AAA domain

    8. NM_167652.2 → NP_728250.1  6-phosphofructo-2-kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728250.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074488
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    9. NM_167655.2 → NP_728253.1  6-phosphofructo-2-kinase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074487
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    10. NM_001258822.2 → NP_001245751.1  6-phosphofructo-2-kinase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    11. NM_001258823.2 → NP_001245752.1  6-phosphofructo-2-kinase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    12. NM_167653.3 → NP_728251.1  6-phosphofructo-2-kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Related
      FBpp0074489
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase

    13. NM_001298511.1 → NP_001285440.1  6-phosphofructo-2-kinase, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL9, Q0KHQ6
      Conserved Domains (2) summary
      pfam00300
      Location:288 → 471
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:74 → 285
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHQ6 Q0KHQ6
    Q9VWH7 Q9VWH7
    Q9Y1W3 Q9Y1W3
    X2JED9 X2JED9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous