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    ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 327705, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ASAP1provided by VGNC
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by VGNC
    Primary source
    VGNC:VGNC:26184
    See related
    BGD:BT21266; Ensembl:ENSBTAG00000003185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DDEF1; DEF-1
    Orthologs
    human mouse all
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    Genomic context

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    See ASAP1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (10264408..10604312)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 8 Neighboring gene small ribosomal subunit protein eS25-like Neighboring gene uncharacterized LOC132342179 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene CYFIP related Rac1 interactor B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. King FJ, et al. Mol Cell Biol, 1999 Mar. PMID 10022919, Free PMC Article
    2. ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Brown MT, et al. Mol Cell Biol, 1998 Dec. PMID 9819391, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Names
    130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
    130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
    ADP-ribosylation factor-directed GTPase-activating protein 1
    ARF GTPase-activating protein 1
    PIP2-dependent ARF1 GAP
    development and differentiation enhancing factor 1
    differentiation-enhancing factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175821.3 → NP_787015.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      DAAA02037608, DAAA02037617, EE241806
      UniProtKB/Swiss-Prot
      O97902
      Conserved Domains (8) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1071 → 1127
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:604 → 692
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:604 → 637
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:442 → 558
      ArfGap; Putative GTPase activating protein for Arf
      cl25800
      Location:954 → 1071
      GGN; Gametogenetin
      cl26464
      Location:755 → 1059
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10264408..10604312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015474408.3 → XP_015329894.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O97902
      Conserved Domains (8) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1068 → 1124
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:601 → 689
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:326 → 411
      PH; PH domain
      pfam01412
      Location:439 → 555
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:582 → 667
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:601 → 634
      ANK; ANK repeat [structural motif]

    2. XM_025001432.2 → XP_024857200.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O97902
      UniProtKB/TrEMBL
      A0A3Q1MGK5
      Related
      ENSBTAP00000069704.2, ENSBTAT00000085115.2
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1011 → 1067
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:601 → 689
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:601 → 634
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:439 → 555
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:725 → 999
      Atrophin-1; Atrophin-1 family

    3. XM_059893135.1 → XP_059749118.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MKJ4
      Related
      ENSBTAP00000071411.2, ENSBTAT00000068902.2

    4. XM_025001431.2 → XP_024857199.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O97902
      Related
      ENSBTAP00000045295.5, ENSBTAT00000048214.5
      Conserved Domains (8) summary
      cd07641
      Location:34 → 248
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1048 → 1104
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:581 → 669
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:296 → 402
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:581 → 614
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:419 → 535
      ArfGap; Putative GTPase activating protein for Arf
      cl25800
      Location:931 → 1048
      GGN; Gametogenetin
      cl26464
      Location:732 → 1036
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97902.1 GenPept UniProtKB/Swiss-Prot:O97902

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