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    Spt7 Spt7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Spt7provided by FlyBase
    Official Full Name
    Spt7provided by FlyBase
    Primary source
    FLYBASE:FBgn0030874
    Locus tag
    Dmel_CG6506
    See related
    AllianceGenome:FB:FBgn0030874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6506; CG6506; Dmel\CG6506; dSpt7
    Summary
    Predicted to enable transcription coactivator activity. Involved in histone H3 acetylation. Located in nucleus. Part of SAGA complex. Is expressed in organism. Orthologous to human SUPT7L (SPT7 like, STAGA complex subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Spt7 in Genome Data Viewer
    Location:
    16E1-16E1; 1-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17850460..17851889)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17744493..17745922)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene TBP-associated factor 9 Neighboring gene uncharacterized protein Neighboring gene Uncoupling protein 4A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 4 Neighboring gene antisense RNA:CR43981 Neighboring gene Sulfiredoxin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability. Torres-Zelada EF, et al. J Cell Sci, 2019 Jan 16. PMID 30559249, Free PMC Article
    2. The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters. Soffers JHM, et al. PLoS Genet, 2021 Nov. PMID 34807910, Free PMC Article
    3. Insights into SAGA function during gene expression. Rodríguez-Navarro S. EMBO Rep, 2009 Aug. PMID 19609321, Free PMC Article
    4. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Mohan RD, et al. Genes Dev, 2014 Feb 1. PMID 24493646, Free PMC Article
    5. The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation. Guelman S, et al. Mol Cell Biol, 2006 Oct. PMID 16980620, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spt7
    Names
    CG6506-PA
    Spt7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17850460..17851889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133020.4 → NP_573248.2  Spt7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573248.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSV3, Q9VX12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX12 Q9VX12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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