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    mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like [ Danio rerio (zebrafish) ]

    Gene ID: 327496, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mthfd2lprovided by ZNC
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5707
    See related
    Ensembl:ENSDARG00000054199 AllianceGenome:ZFIN:ZDB-GENE-030131-5707
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63479; wu:fi14c12
    Summary
    Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in mitochondrion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mthfd2l in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (32386290..32405069)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (32380604..32394588)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene importin 11 Neighboring gene adhesion G protein-coupled receptor F5-like Neighboring gene lipase, endothelial Neighboring gene uncharacterized LOC137496365 Neighboring gene epithelial mitogen homolog (mouse)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Disruption of the folate pathway in zebrafish causes developmental defects. Lee MS, et al. BMC Dev Biol, 2012 Apr 5. PMID 22480165, Free PMC Article
    2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
    NP_956107.1
    XP_005167203.1
    XP_068078970.1
    XP_068078971.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199813.1 → NP_956107.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

      See identical proteins and their annotated locations for NP_956107.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055121
      UniProtKB/TrEMBL
      Q7SY55
      Related
      ENSDARP00000070824.4, ENSDART00000076350.6
      Conserved Domains (3) summary
      cd01080
      Location:150 → 329
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PRK14190
      Location:50 → 329
      PRK14190; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional
      pfam00763
      Location:53 → 155
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      32386290..32405069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222870.1 → XP_068078971.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X3

    2. XM_005167146.5 → XP_005167203.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEG5
      Conserved Domains (3) summary
      cd01080
      Location:164 → 343
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PRK14190
      Location:50 → 343
      PRK14190; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional
      pfam00763
      Location:53 → 169
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    3. XM_068222869.1 → XP_068078970.1  probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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