rnf2 ring finger protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rnf2provided by ZNC
Official Full Name: ring finger protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5243
See related: Ensembl:ENSDARG00000010381 AllianceGenome:ZFIN:ZDB-GENE-030131-5243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ring1b; wz4556; wz4566; fa19h05; wu:fa19h05
Summary: Predicted to enable chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nervous system development. Predicted to be located in nuclear body. Predicted to be part of MLL1 complex and PRC1 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in gonad; gut; muscle; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (23351451..23361940)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (23695800..23706289)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction.
Title: PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction.
Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development.
Title: Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development.
The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.
Title: The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.
These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.
Title: The Polycomb group protein Ring1b is essential for pectoral fin development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AK119 ubiquitin ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axis specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac conduction system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neural crest cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina morphogenesis in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RING2

Names: RING-type E3 ubiquitin transferase RING2; ring finger protein 1b

NP_571288.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131213.2 → NP_571288.2 E3 ubiquitin-protein ligase RING2

Status: VALIDATED

Source sequence(s)

BX470197, EH435872, EH593592, EH599086

UniProtKB/Swiss-Prot

Q6PUR9, Q803I4, Q9PTH4

UniProtKB/TrEMBL

A0A0H2UKC6, A0A8M1PAV1

Related

ENSDARP00000002609.7, ENSDART00000017034.8

Conserved Domains (2) summary

pfam00097
Location:53 → 92

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam16207
Location:239 → 332

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like