Arp2 Actin-related protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arp2provided by FlyBase
Official Full Name: Actin-related protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0011742
Locus tag: Dmel_CG9901
See related: AllianceGenome:FB:FBgn0011742
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Actr14D; Arp14d; Arp14D; ARP14D; arp2; ARP2; CG9901; Dmel\CG9901
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in several processes, including positive regulation of synaptic assembly at neuromuscular junction; regulation of filopodium assembly; and terminal button organization. Predicted to be located in actin filament. Predicted to be part of Arp2/3 protein complex. Is expressed in several structures, including adult head; embryonic/larval gut; extended germ band embryo; larval ventral nerve cord; and presumptive embryonic/larval central nervous system. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 14E1-14E1; 1-54 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16548290..16553968, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16442323..16448001, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material.
Title: Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material.
Cofilin promotes phosphate dissociation and severs filaments, generating new pointed ends and rendering Arp2/3-generated networks competent to bind tropomyosin
Title: Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks.
Arp2/3 has an essential role in the process of secretory cargo expulsion and integration of vesicular membranes with the apical plasma membrane.
Title: Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo.
Abp1 and Arp2/3 complex-mediated actin cytoskeletal dynamics drive both synaptic bouton formation and neuromuscular junction branching.
Title: Terminal axonal arborization and synaptic bouton formation critically rely on abp1 and the arp2/3 complex.
Arp2/3 has a role in PI(4,5)P2 regulation of myoblast fusion in Drosophila
Title: PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site.
The data indicate that WASp-dependent Arp2/3 actin polymerization is crucial for apical presentation of Delta, providing a mechanistic link between actin polymerization and Notch signalling.
Title: The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors.
The Arp2/3 complex is required for actin cap expansion and pseudocleavage furrow formation during the syncytial blastoderm divisions.
Title: Arp2/3-dependent pseudocleavage [correction of psuedocleavage] furrow assembly in syncytial Drosophila embryos.
two actin regulators, capping protein, a barbed end binding protein, and the Arp2/3 complex, a potent actin assembly nucleator, function to generate properly organized bundles.
Title: Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Actin-related protein 2

Names: Actin-related protein 14 Da; Actin-related protein 14D; Arp14D; Arp2-PA; Arp2-PB; Arp2-PC; CG9901-PA; CG9901-PB; CG9901-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

16548290..16553968 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103531.2 → NP_001097001.1 Actin-related protein 2, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P45888

Conserved Domains (1) summary

smart00268
Location:6 → 388

ACTIN; Actin
NM_078648.4 → NP_523372.2 Actin-related protein 2, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P45888

Related

FBpp0074070

Conserved Domains (1) summary

smart00268
Location:6 → 388

ACTIN; Actin
NM_001272692.1 → NP_001259621.1 Actin-related protein 2, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JV17, F0JAK9, P45888, Q9VXF3

Conserved Domains (1) summary

smart00268
Location:6 → 393

ACTIN; Actin