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    sephs1 selenophosphate synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 324947, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sephs1provided by ZNC
    Official Full Name
    selenophosphate synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3670
    See related
    Ensembl:ENSDARG00000058292 AllianceGenome:ZFIN:ZDB-GENE-030131-3670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55304; wu:fc49b09
    Summary
    Predicted to enable protein heterodimerization activity; protein homodimerization activity; and selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human SEPHS1 (selenophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See sephs1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (8367602..8380262, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (8409583..8422243, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain-containing protein 13 Neighboring gene carnitine palmitoyltransferase 1B (muscle) Neighboring gene BEN domain containing 7 Neighboring gene PRP18 pre-mRNA processing factor 18 homolog (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation. Benner MJ, et al. Physiol Genomics, 2013 Aug 1. PMID 23737534, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables selenide, water dikinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables selenide, water dikinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in selenocysteine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    selenide, water dikinase 1
    Names
    selenium donor protein 1
    selenophosphate synthase 1
    NP_955995.2
    XP_005159063.1
    XP_068070826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199701.2 → NP_955995.2  selenide, water dikinase 1

      See identical proteins and their annotated locations for NP_955995.2

      Status: VALIDATED

      Source sequence(s)
      BC045302, CN510578, CT658572, EB797523, EE312480
      UniProtKB/Swiss-Prot
      Q1LXT8, Q7ZW38
      Related
      ENSDARP00000075586.4, ENSDART00000081143.6
      Conserved Domains (2) summary
      cd02195
      Location:20 → 357
      SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
      TIGR00476
      Location:19 → 333
      selD; selenium donor protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      8367602..8380262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159006.5 → XP_005159063.1  selenide, water dikinase 1 isoform X1

      See identical proteins and their annotated locations for XP_005159063.1

      UniProtKB/Swiss-Prot
      Q1LXT8, Q7ZW38
      Related
      ENSDARP00000148109.1, ENSDART00000192807.1
      Conserved Domains (2) summary
      cd02195
      Location:20 → 357
      SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
      TIGR00476
      Location:19 → 333
      selD; selenium donor protein

    2. XM_068214725.1 → XP_068070826.1  selenide, water dikinase 1 isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395004.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      130..8135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZW38.2 GenPept UniProtKB/Swiss-Prot:Q7ZW38

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