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    chsy1 chondroitin sulfate synthase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 324407, updated on 2-Nov-2024

    Summary

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    Official Symbol
    chsy1provided by ZNC
    Official Full Name
    chondroitin sulfate synthase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3127
    See related
    Ensembl:ENSDARG00000079027 AllianceGenome:ZFIN:ZDB-GENE-030131-3127
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    chys1; zgc:64191; wu:fc27h05; wu:fc27h06
    Summary
    Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Acts upstream of or within several processes, including chondroitin sulfate proteoglycan biosynthetic process; pectoral fin development; and sensory organ morphogenesis. Predicted to be located in Golgi cisterna membrane. Is expressed in several structures, including central nervous system; cranium; inner ear; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See chsy1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (9326234..9511298)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (9080747..9265811)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene selenoprotein S Neighboring gene leucine-rich repeat kinase 1 Neighboring gene aldehyde dehydrogenase 1 family, member A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic exposure to an aqueous coal dust extract results in gene expression alterations associated with the development and function of connective tissue and the hematological system, immunological and inflammatory disease, and cancer in zebrafish. Caballero-Gallardo K, et al. Metallomics, 2018 Mar 1. PMID 29485154
    2. Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling. Li Y, et al. Am J Hum Genet, 2010 Dec 10. PMID 21129728, Free PMC Article
    3. Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development. Habicher J, et al. PLoS Genet, 2022 Feb. PMID 35192612, Free PMC Article
    4. Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development. Filipek-Górniok B, et al. Dev Dyn, 2013 Aug. PMID 23703795
    5. Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Peal DS, et al. Dev Dyn, 2009 Dec. PMID 19890913, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chondroitin sulfate expression is required for cardiac atrioventricular canal formation.
      Title: Chondroitin sulfate expression is required for cardiac atrioventricular canal formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pectoral fin development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within semicircular canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate synthase 1
    Names
    carbohydrate (chondroitin) synthase 1
    NP_997843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212678.1 → NP_997843.1  chondroitin sulfate synthase 1 precursor

      See identical proteins and their annotated locations for NP_997843.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064670
      UniProtKB/TrEMBL
      A0A8M1PHH7, Q6P296
      Related
      ENSDARP00000095309.3, ENSDART00000104536.5
      Conserved Domains (2) summary
      pfam05679
      Location:236 → 775
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:85 → 306
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      9326234..9511298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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