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    sev sevenless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32039, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sevprovided by FlyBase
    Official Full Name
    sevenlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003366
    Locus tag
    Dmel_CG18085
    See related
    AllianceGenome:FB:FBgn0003366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7LES; 7less; CG18085; CT3980; Dmel\CG18085; DmHD-265; DROSEV; DROSEV1; HD-265; Sev; SEV; sev(AC)[[14]]
    Summary
    Enables boss receptor activity. Involved in germ-line stem-cell niche homeostasis; peptidyl-tyrosine autophosphorylation; and sevenless signaling pathway. Is integral component of plasma membrane. Is expressed in adult head; gonad; and imaginal disc. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sev in Genome Data Viewer
    Location:
    10A4-10A4; 1-33 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11071441..11086299, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10965474..10980332, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45614 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44358 Neighboring gene antisense RNA:CR45604 Neighboring gene vago Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRiP stocks contain a previously uncharacterized loss-of-function sevenless allele. Escobedo S, et al. MicroPubl Biol, 2019 Apr 4. PMID 32550423, Free PMC Article
    2. The commonly used eye-specific sev-GAL4 and GMR-GAL4 drivers in Drosophila melanogaster are expressed in tissues other than eyes also. Ray M, et al. J Genet, 2015 Sep. PMID 26440079
    3. Cell fate in the Drosophila ommatidium. Tomlinson A, et al. Dev Biol, 1987 Sep. PMID 17985474
    4. Sevenless: a cell-specific homeotic mutation of the Drosophila eye. Tomlinson A, et al. Science, 1986 Jan 24. PMID 17735014
    5. The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7. Banerjee U, et al. Cell, 1987 Oct 9. PMID 3115594

    See all (520) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and Dynamics of Drk-SH2 Domain and Its Site-Specific Interaction with Sev Receptor Tyrosine Kinase.
      Title: Structure and Dynamics of Drk-SH2 Domain and Its Site-Specific Interaction with Sev Receptor Tyrosine Kinase.
    2. Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
      Title: The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.
    3. We show that Rap1 activity induces and/or maintains the formation of the apical domain of developing photoreceptor cells and that this event correlates with the apical accumulation and activity of SEV in presumptive R7 cells.
      Title: Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.
    4. Possibility of conserved Sevenless signaling controlled patterning processes in endopterygote insects.
      Title: Fast co-evolution of sevenless and bride of sevenless in endopterygote insects.
    5. Sevenless (Sev), is required to ensure that the niche develops in the anterior region of the male embryonic gonads
      Title: Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables boss receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R7 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sevenless signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sevenless
    Names
    CG18085-PA
    sev-PA
    NP_511114.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11071441..11086299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078559.3 → NP_511114.2  sevenless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511114.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13368, Q9TYI0, Q9U5V7, Q9VZ36
      Related
      FBpp0073249
      Conserved Domains (6) summary
      smart00060
      Location:1292 → 1374
      FN3; Fibronectin type 3 domain
      smart00135
      Location:993 → 1026
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00063
      Location:1799 → 1897
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05044
      Location:2213 → 2483
      PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
      pfam00041
      Location:439 → 520
      fn3; Fibronectin type III domain
      pfam07714
      Location:2209 → 2481
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13368.2 P13368
    Q6SDF2 Q6SDF2
    Q6SDM8 Q6SDM8
    Q6SDN2 Q6SDN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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